Aquaponics, defined as a sustainable technology combining aquaculture and hydroponics, integrates plant and fish production into one system. Aquaponics technology offers several major advantages over conventional methods of raising fish and/or plants. In this system, plants act as a natural biological filter, purifying the water so that the same amount can be used repeatedly. Fish, on the other hand, are a natural source of nutrients. This contributes to the aquaponics system’s substantial economic potential, thanks to its use of virtually free nutrients, dramatically reduced water consumption, and the elimination of filter systems, making this system innovative and sustainable. On the other hand, the use of medicinal plants for the needs of the pharmaceutical, cosmetics, and food industries is often associated with a decrease in their natural reserves. Utilizing aquaponics for the production of medicinal plants could reduce the pressure on these natural reserves. As a result, aquaponics has emerged as one of the most environmentally friendly methods of cultivating plant species. The concept of aquaponics, which evolved from traditional hydroponic systems, has gained worldwide recognition through the effective use of symbiosis. It refers to the coexistence and interaction of different organisms, facilitating their growth and life cycle processes. Unlike hydroponics, which requires the purification of nutrient solutions due to plant waste, aquaponics takes advantage of the natural cycle of waste and nutrient exchange between plants and fish. Fish waste serves as organic fertilizer for the plants, while the plants help purify the water for the fish. This symbiotic relationship not only reduces the environmental impact associated with aquaculture wastewater but also provides a sustainable method of food production. The integrated system reduces infrastructure costs, conserves water, and minimizes the potential for environmental pollution. Furthermore, it provides an opportunity for increased profitability from both crop and fish production. Cultivation of medicinal plants within aquaponic systems can be carried out year-round, offering a continuous supply of valuable pharmacological resources. This review examines suitable medicinal plants for aquaponic cultivation and evaluates their pharmacological benefits to humans.