Review on infectious Bursal disease : Threat for Ethiopian Poultry industry

Arega, Aregitu Mekuriaw

doi:10.26627/ijals/2018/11.01.0047

Cited by 4 publications

(1 citation statement)

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“…Infectious bursal disease (IBD) is a viral disease of chicken caused by infectious bursal disease virus (IBDV) [59,60,61,62]. IBDV is a non-enveloped virus that belongs to the genus Avibirnavirus and the Birnaviridae family [62,63,64,65,66].…”

Section: Introductionmentioning

confidence: 99%

Current Findings on Gut Microbiota Mediated Immune Modulation against Viral Diseases in Chicken

Abaidullah

Peng

Kamran

et al. 2019

Viruses

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Chicken gastrointestinal tract is an important site of immune cell development that not only regulates gut microbiota but also maintains extra-intestinal immunity. Recent studies have emphasized the important roles of gut microbiota in shaping immunity against viral diseases in chicken. Microbial diversity and its integrity are the key elements for deriving immunity against invading viral pathogens. Commensal bacteria provide protection against pathogens through direct competition and by the production of antibodies and activation of different cytokines to modulate innate and adaptive immune responses. There are few economically important viral diseases of chicken that perturb the intestinal microbiota diversity. Disruption of microbial homeostasis (dysbiosis) associates with a variety of pathological states, which facilitate the establishment of acute viral infections in chickens. In this review, we summarize the calibrated interactions among the microbiota mediated immune modulation through the production of different interferons (IFNs) ILs, and virus-specific IgA and IgG, and their impact on the severity of viral infections in chickens. Here, it also shows that acute viral infection diminishes commensal bacteria such as Lactobacillus, Bifidobacterium, Firmicutes, and Blautia spp. populations and enhances the colonization of pathobionts, including E. coli, Shigella, and Clostridial spp., in infected chickens.

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