Review on: New approaches in self micro-emulsifying drug delivery system

Misal, Ravindranath S.; Potphode, Vishawas R.; Mahajan, Vijay R.

doi:10.5958/0974-360x.2017.00218.9

Cited by 6 publications

(3 citation statements)

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“…SMEDDS is a preconcentrate that spontaneously forms microemulsions in an aqueous solution under gentle agitation. To form the microemulsion, the entropy change for dispersion should be greater than the energy for the increase in surface area, and the free energy (Δ G ) should be negative. , In formulation studies, the oil, surfactant, and cosurfactant with high drug solubility are selected, and the ratio of ingredients is decided by constructing a pseudoternary phase diagram. Examples of SMEDDS products include Neoral solubilizing cyclosporine A, and Fortovase for saquinavir .…”

Section: Amount-controlled Ddsmentioning

confidence: 99%

Oral Drug Delivery Systems Applied to Launched Products: Value for the Patients and Industrial Considerations

Yoshida,

Kojima

2023

Mol. Pharmaceutics

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Drug delivery systems (DDS) control the amount, rate, and site of administration of drug substances in the body as well as their release and ADME (absorption, distribution, metabolism, excretion). Among the various types of DDS, amount-controlled DDS for solubilization and absorption increase the bioavailability. Time-and amount-controlled DDS are controlled release formulations classified as (1) membrane-type, (2) matrix-type, (3) osmotic-type, and (4) ion-exchange type. Timed-release formulations also control the time and amount of release and the absorption of drugs. Site-and amount-controlled DDS are characterized by colonic delivery and intestinal lymphtargeting to improve release and ADME of drug substances. Finally, site-, time-, and amount-controlled DDS are gastroretentive formulations and local delivery in the oral cavity to improve site retention, release, and ADME of drugs. DDS can enhance efficacy, reduce adverse effects, and optimize the dosing frequency of various drug products to increase patient value. This review focuses on patient value and industrial considerations of launched oral DDS. We provide a technological overview of candidate and marketed DDS, as well as the pros/cons of the technologies for industrialization with consideration to excipients, manufacturing, and storage stability. Moreover, to demonstrate the usefulness of the technology and support the selection and development of the best technologies for patients, we also describe patient value from clinical studies and analyses, particularly with regard to increased new medical options, higher efficacy, reduced adverse effects, reduced number of doses and clinic visits, easier administration, higher quality of life, greater adherence, and satisfaction.

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Section: Amount-controlled Ddsmentioning

confidence: 99%

Oral Drug Delivery Systems Applied to Launched Products: Value for the Patients and Industrial Considerations

Yoshida,

Kojima

2023

Mol. Pharmaceutics

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“…Hydrogels are widely used in the field of drug delivery, tissue engineering, regenerative medicine, food industries as well as fashionable showcase materials providing safety cushion and identity to the biomedical device [9,10]. In pharmaceuticals, the peptide, MIP, nanofiller enhanced hydrogels are being considered as drug delivery system [11,12]. Designing of the biomaterial surface can turn the material into smart biomaterial, and this surface modulation, e.g., for cell adhesion [13], chemo-selective conjugation of biologicals [14], etc.…”

Section: Advances In Hydrogelsmentioning

confidence: 99%

Advanced Hydrogels for Biomedical Applications

Singh

2018

BJSTR

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Gels or hydrogels are described as the matrix of cross-linked polymers. Hydrogels are naturally a part of the body in the form of collagen, gelatin, mucous, tear films, cartilage, vitreous humor, cornea, and tendon. Collagen, gelatin, and nanofillers can be used to modify the strength of hydrogels. Use of biodegradable hydrogel scaffold is ideal for tissue regeneration, where the scaffold degrades as the tissue regeneration occurs. The hydrogel can be lone or composition of fundamental properties such as edible, non-edible, biodegradable, non-biodegradable, injectable, topical, natural, synthetic, physically crosslinked, chemically cross-linked. During past three decades hydrogels due to various factors such as biodegradable, absorbent, tissue resemblance and easy use, have received the enormous attention from researchers around the globe. Although hydrogels have become part of a variety of industries but quest for biomedical application of hydrogels is ongoing. This review addresses the recent advances in different forms of hydrogels and their biomedical use.

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“…[1] Based on the droplet size after emulsification, they are classified into two broad classes, namely selfemulsifying drug delivery systems (SEDDS) with a droplet size range of 100-300 nm and self-microemulsifying drug delivery systems (SMEDDS) with a droplet size range <50 nm. [2] As a result of the lower globule size, the micro/nanoemulsified drug can be taken up efficiently through lymphatic pathways, where it bypasses the hepatic first-pass effect. [3] Larger lipid droplet which represents SMEDDS or microemulsions is converted into smaller micelles on coming in contact with bile salts and lipases.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Betageri¹

2019

AJP

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Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase solubility and bioavailability of poorly soluble drugs. SEDDS are isotropic mixtures, consisting of oils, surfactants, and sometimes cosolvents. Designed formulations are used to improve the oral absorption of highly lipophilic compounds. Multiple lipid-based drug delivery systems are widely reported in literature and they include simple oil solutions, coarse, multiple and dry emulsions, and more complex self-emulsifying, microemulsifying or nanoemulsifying drug delivery systems. The process of self-emulsification is dependent on diverse factors such as the nature of oil, surfactant, cosurfactant, oil/surfactant ratio, and the polarity of the emulsion. Considering the ease of large-scale production and the robustness of SEDDS, several formulations are commercially available which utilize this technology. This article attempts to present an overview of SEDDS along with their applications, compiled literature data, commercially available products, and their descriptions.

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Review on: New approaches in self micro-emulsifying drug delivery system

Cited by 6 publications

References 0 publications

Oral Drug Delivery Systems Applied to Launched Products: Value for the Patients and Industrial Considerations

Oral Drug Delivery Systems Applied to Launched Products: Value for the Patients and Industrial Considerations

Advanced Hydrogels for Biomedical Applications

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