The Indian traditional system of conventional medication includes an enormous lexis of herbal preparations and medicinal plants. They are optional nutrients that are mostly produced by plants as a form of defence. These items may include isolated nutrients, nutritional supplements, particular diets, herbal products, processed foods, and drinks. They may also include genetically modified designer foods. Phytochemicals are naturally occurring compounds that can be found in a variety of foods, including legumes, fruits, vegetables, whole grains, and herbs. These substances include polyphenols, flavonoids, isoflavonoids, anthocyanidins, phytoestrogens, terpenoids, carotenoids, limonoids, phytosterols, glucosinolates, and fibers. Phytochemicals are known to have a significant impact on human health, with potential medical benefits that can help prevent and treat a range of illnesses and physiological abnormalities.Phytochemicals have been shown to have various pharmacological effects on human health, including acting as powerful antioxidants, antibacterial and antifungal agents, antiinflammatory and anti-allergic compounds, antispasmodic agents, chemo preventive agents, hepatoprotective agents, neuroprotective agents, as well as hypolipidemic and hypotensive agents. Therefore, these compounds are of great interest in the fields of medicine, nutrition, and health science. They also induce apoptosis, act as a diuretic, stimulate the central nervous system, modulate the immune response, and act as a carminative, analgesic. It is necessary for herbal products to undergo quality control, thorough testing to determine their efficacy and safety, and reliable clinical trials. To give improved health care services to the public, the meticulous and scientific integration of India's traditional system of herbal medicine into evidence-based clinical illness management is crucial. Thus, this chapter focuses on the integration and advancement of herbal-based medicines through the scientific validation of some clinically important bioactive phytochemicals.