Review on potential effects of traditional Chinese medicine on glaucoma

Qi, Si-Min; Zhang, Jing-Tian; Zhu, Hongyan; Wang, Zi; Li, Wei

doi:10.1016/j.jep.2022.116063

Cited by 7 publications

(3 citation statements)

References 61 publications

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“…In Traditional Chinese Medicine (TCM), it is believed to help prevent cardiovascular diseases, cancer (such as stomach, oral, and esophageal cancers), and metabolic syndrome [ 16 , 17 ]. In Ayurvedic medicine, GT has been used for gastrointestinal diseases [ 18 ].TCM has employed GT in medicinal applications for eye diseases such as glaucoma, diabetic retinopathy, and dry eye disease [ [19] , [20] , [21] ]. Traditional Persian medicine also recognized the therapeutic benefits of GT, using it for eye swelling and infection [ 22 ].…”

Section: Traditional Medicine Applicationsmentioning

confidence: 99%

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Boroughani,

Tahmasbi,

Heidari

et al. 2024

Heliyon

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Section: Traditional Medicine Applicationsmentioning

confidence: 99%

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Boroughani,

Tahmasbi,

Heidari

et al. 2024

Heliyon

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“…A study indicated a growing interest in the regulation of lymphatic vessels by TCM ( 99 ). Although current research primarily focuses on arthritis and lymphedema, there are numerous promising signs that TCM can improve microcirculation in the eyes and brain, while also regulating local oxidative stress and immune responses ( 100 , 101 ). These findings prompt us to consider the potential role of TCM in regulating lymphatic vessels, providing a promising perspective for further exploration.…”

Section: Traditional Chinese Medicine Regulating Lymphangiogenesismentioning

confidence: 99%

Lymphangiogenesis: A new strategy for heart disease treatment (Review)

Bai,

Wang,

et al. 2024

Int J Mol Med

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Heart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays a crucial role in regulating essential physiological processes, including fluid balance, transportation of extravasated proteins and immune cell trafficking, all of which are important for heart function. Through thorough scientometric analysis and extensive research, the present review identified lymphangiogenesis as a hotspot in cardiovascular disease research, and the mechanisms underlying impaired cardiac lymphangiogenesis and inadequate lymph drainage in various cardiovascular diseases are discussed. Furthermore, the way used to improve lymphangiogenesis to effectively regulate a variety of heart diseases and associated signaling pathways was investigated. Notably, the current review also highlights the impact of Traditional Chinese Medicine (TCM) on lymphangiogenesis, aiming to establish a clinical basis for the potential of TCM to improve cardiovascular diseases by promoting lymphangiogenesis.

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“…The multi-component, multi-target, and multi-channel characteristics of Chinese traditional veterinary medicine have made it difficult to elucidate the complex mechanisms, leading to a lack of data in pharmacological research. Network pharmacology has created a new framework for investigating how medications and disorders interact (14,15).…”

Section: Introductionmentioning

confidence: 99%

Study on the mechanism of Wumei San in treating piglet diarrhea using network pharmacology and molecular docking

Yin

Liu²,

Ji³

et al. 2023

Front. Vet. Sci.

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Wumei San (WMS) is a traditional Chinese medicine that has been widely applied in the treatment of piglet diarrhea (PD). However, the mechanism of WMS in PD has not been investigated. In this study, the main active compounds of WMS and the target proteins were obtained from the Traditional Chinese Medicine Systematic Pharmacology, PubChem, and SwissTargetPrediction databases. The molecular targets of PD were identified using GeneCards, OMIM, and NCBI databases. The common targets of WMS and PD were screened out and converted into UniProt gene symbols. PD-related target genes were constructed into a protein-protein interaction network, which was further analyzed by the STRING online database. Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to construct the component-target gene-disease network. Molecular docking was then used to examine the relationship between the core compounds and proteins. As a result, a total of 32 active compounds and 638 target genes of WMS were identified, and a WMS-compound-target network was successfully constructed. Through network pharmacology analysis, 14 core compounds in WMS that showed an effect on PD were identified. The targets revealed by GO and KEGG enrichment analysis were associated with the AGE-RAGE signaling pathway, PI3K-Akt signaling pathway, TNF signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, and other pathways and physiological processes. Molecular docking analysis revealed that the active compounds in WMS spontaneously bind to their targets. The results indicated that WMS may regulate the local immune response and inflammatory factors mainly through the TNF signaling pathway, IL-17 signaling pathway, and other pathways. WMS is a promising treatment strategy for PD. This study provides new insights into the potential mechanism of WMS in PD.

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Review on potential effects of traditional Chinese medicine on glaucoma

Cited by 7 publications

References 61 publications

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Lymphangiogenesis: A new strategy for heart disease treatment (Review)

Study on the mechanism of Wumei San in treating piglet diarrhea using network pharmacology and molecular docking

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