Review on the Applications and Molecular Mechanisms of<i>Xihuang</i>Pill in Tumor Treatment

Guo, Qiujun; Lin, Jinyin; Li, Rui; Gao, Yebo; He, Shulin; Xu, Xinyao; Bai, Hua; Li, Conghuang; Hou, Wei; Zheng, Hongliang; Bao, Yanju

doi:10.1155/2015/854307

Cited by 45 publications

(37 citation statements)

References 80 publications

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“…Xihuang pill is a complementary and alternative medicine that has been used in TCM due to the inhibition for tumor cell proliferation [6]. Xihuang pill is composed of Ru Xiang (olibanum), Mo Yao (Commiphora myrrha), She Xiang (Moschus), and Niu Huang (calculus bovis), which exert multiple antitumor effects [7]. A previous study shows that Xihuang pill has an anticancer effect on breast tumor [8], gastric cancer, and primary liver cancer [7].…”

Section: Introductionmentioning

confidence: 99%

“…Xihuang pill is composed of Ru Xiang (olibanum), Mo Yao (Commiphora myrrha), She Xiang (Moschus), and Niu Huang (calculus bovis), which exert multiple antitumor effects [7]. A previous study shows that Xihuang pill has an anticancer effect on breast tumor [8], gastric cancer, and primary liver cancer [7]. Actually, Xihuang pill could improve quality of life and clinical manifestations of advanced primary liver cancer patients [9].…”

Section: Introductionmentioning

confidence: 99%

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Network Pharmacology‐Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer

Hao

Chen

2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the potential therapy targets and pharmacological mechanism of traditional Chinese medicine (TCM) Xihuang pill in liver cancer based on network pharmacology. Methods. Drug ingredients-target network was constructed based on the target sets of Xihuang pill and liver cancer. e overlapping genes between Xihuang pill targets and liver cancer-related molecular targets were investigated using comparative analysis. Moreover, the PPI network and module was constructed based on overlapping genes and hub nodes, respectively, followed by the pathway enrichment analysis. Results. A drug ingredients-target network was established with 1184 nodes and 11035 interactions. Moreover, a total of 106 overlapping genes were revealed between drug targets and liver cancer molecular targets. Furthermore, a PPI network and 4 modules were further investigated based on overlapping genes, respectively. ese hub nodes such as VEGFA and EGFR were mainly enriched in GO functions including positive regulation of MAP kinase activity, activation of protein kinase activity, regulation of MAP kinase activity, and pathways like proteoglycans in cancer, bladder cancer, and estrogen signaling. Conclusion. VEGFA and EGFR might be potential therapy targets of Xihuang pill in liver cancer. Furthermore, the effect of Xihuang pill on liver cancer might be realized by targeting VEGFA and EGFR in pathways like proteoglycans in cancer and estrogen signaling.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Network Pharmacology‐Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer

Hao

Chen

2020

Evidence-Based Complementary and Alternative Medicine

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“…[ 4 ] It is accepted in China to enhance the antitumor effects of conventional therapies, reduce the toxicity of chemotherapy and radiotherapy, alleviate tumor-induced clinical symptoms and cancer pain, and prolong the survival time of postoperational and advanced-stage cancer patients. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Xihuang pill for lung cancer

Wang

Hou

Peng³

et al. 2020

Medicine

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Background: Xihuang pill, a famous traditional Chinese medicine formulation, is a broad-spectrum anti-tumor drug and has been widely used for the treatment of lung cancer in China. The aim of this study is to systematically investigate the efficacy and safety of Xihuang pill for the treatment of lung cancer. Methods: We will perform the comprehensive literature search in the following databases from their inceptions to August 2020 for data extraction: PubMed, the Cochrane Library, Embase, the China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, and Chinese Biomedical Literature Database. Cochrane Risk of Bias tool will be used to assess the risk of bias of included studies. The RevMan 5.4 and Stata 16.0 software will be applied for statistical analyses. Statistical heterogeneity will be computed by I 2 tests. Sensitivity analysis will be conducted to evaluate the stability of the results. The publication bias will be evaluated by funnel plots and Egger test. The quality of evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluate system (GRADE) system. Results: The results of our research will be published in a peer-reviewed journal. Conclusion: The conclusion of this study will provide evidence to show whether Xihuang pill is an effective intervention for patient with lung cancer. OSF registration number: 10.17605/OSF.IO/W2GHN

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“…Traditional Chinese medicine (TCM) honors a long history in tumor treatment and it is accepted that TCM can inhibit tumor growth and metastasis, improve antitumor immunity, relieve tumor pains, and reduce side-effects of chemotherapy [ 3 – 5 ]. Combined treatment of TCM and modern medicine is widely used for AGC in China and studies showed TCM had an important potential value for improving the prognosis of patients with AGC [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cinobufacini Injection Improves the Efficacy of Chemotherapy on Advanced Stage Gastric Cancer: A Systemic Review and Meta‐Analysis

Zhang

Yuan

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Gastric cancer has a high morbidity and mortality. Chemotherapy regimens are routine advanced stage gastric cancer (AGC) treatment protocols, but most of these drugs have side-effects such as myelosuppression and gastrointestinal disorders. Cinobufacini, an extractive from TCM, could suppress cell proliferation and inhibit gastric cancer. In this study, we comprehensively reviewed the literature on the efficacy comparison between Cinobufacini injection combined with chemotherapy and chemotherapy solely used in AGC treatment. We extracted data for from six electronic databases to evaluate the efficacy of Cinobufacini injection on AGC patients. Twelve studies with a total of 853 patients were finally included in our study. The results indicated that Cinobufacini injection could increase response rate and disease control rate of chemotherapy on AGC, improve the life quality of AGC patients, increase leukocytes, improve anemia, improve hand-foot syndrome induced by chemotherapy, and relieve cancer pain. This study has its own limitations that prevented us from drawing a definite conclusion and more well-designed clinical trials of TCM are needed.

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Review on the Applications and Molecular Mechanisms ofXihuangPill in Tumor Treatment

Cited by 45 publications

References 80 publications

Network Pharmacology‐Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer

Network Pharmacology‐Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer

Efficacy and safety of Xihuang pill for lung cancer

Cinobufacini Injection Improves the Efficacy of Chemotherapy on Advanced Stage Gastric Cancer: A Systemic Review and Meta‐Analysis

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