Review on the Cellular Mechanisms of Low-Level Laser Therapy Use in Oncology

Abstract

Photobiomodulation (PBM) using low-level laser therapy (LLLT) is a treatment that is increasingly used in oncology. Studies reported enhancement of wound healing with reduction in pain, tissue swelling and inflammatory conditions such as radiation dermatitis, oral mucositis, and lymphedema. However, factors such as wavelength, energy density and irradiation frequency influence the cellular mechanisms of LLLT. Moreover, the effects of LLLT vary according to cell types. Thus, controversy arose as a result of poor clinical response reported in some studies that may have used inadequately planned treatment protocols. Since LLLT may enhance tumor cell proliferation, these will also need to be considered before clinical use. This review aims to summarize the current knowledge of the cellular mechanisms of LLLT by considering its effects on cell proliferation, metabolism, angiogenesis, apoptosis and inflammation. With a better understanding of the cellular mechanisms, bridging findings from laboratory studies to clinical application can be improved.

Photobiomodulation therapy prevents dysgeusia chemotherapy induced in breast cancer women treated with doxorubicin plus cyclophosphamide: a triple-blinded, randomized, placebo-controlled clinical trial

“…Dysgeusia is a critical adverse effect in this process, interfering with the nutritional status [5,8]. In this study, PBMT lead to a signi cant increase in BMI, which may be associated with the low incidence of dysgeusia during treatment [30,31].…”

Photobiomodulation Therapy Prevents Dysgeusia Chemotherapy-Induced in Breast Cancer Women Treated with Doxorubicin Plus Cyclophosphamide: A Triple-Blinded, Randomized, Placebo-Controlled Clinical Trial

“…Oppositely to PBMT, the placebo group showed an increase in the degree of tooth mobility. Dysentery is linked to side effects such as nausea and vomiting cravings [8, 29,31,33]. The reduction of these side effects in the present study may have contributed to better oral hygiene and dental health status [34].…”

Autism Spectrum Disorder (ASD): From Molecular Mechanism to Novel Therapeutic Approach

“…In the clinic, 3LT was found to cause an immediate decrease in acute and chronic pain and an increase in function [102,[105][106][107]. 3LT showed promising results for myocardial infraction [108], rejuvenating mesenchymal stem cells [109], skin injuries [110][111][112][113], brain trauma, TBI [114][115][116], diabetic retinopathy [117], oncology [118], and more.…”