Review on the potential application of non-phenolic compounds from native Latin American food byproducts in inflammatory bowel diseases

Nascimento, Roberto de Paula do; Moya, Amanda Maria Tomazini Munhoz; Machado, Ana Paula da Fonseca; Geraldi, Marina Vilar; Diez-Echave, Patrícia; Vezza, Teresa; Gálvez, Júlio; Cazarin, Cínthia Baú Betim; Maróstica, Mário Roberto

doi:10.1016/j.foodres.2020.109796

Cited by 19 publications

(8 citation statements)

References 205 publications

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“…30 Oleic acid, a type of MUFA, might play an anti-inflammatory role due to its ability to inhibit the enzymes responsible for the formation of arachidonic acid, with strong pro-inflammatory properties. 31 A recent study reported that serum oleic acid was decreased in the colitis mice compared to the control group. 12 Therefore, the increased levels of sugiol, β-ionone, and oleic acids in plasma by mEVs is beneficial for suppressing inflammation.…”

Section: Lipids and Lipid-like Moleculesmentioning

confidence: 98%

Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism

Quan

Zhao

et al. 2023

Food Funct.

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Section: Lipids and Lipid-like Moleculesmentioning

confidence: 98%

Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism

Quan

Zhao

et al. 2023

Food Funct.

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“…Food bioactive compounds are naturally occurring substances found in the food matrix, which typically lack nutritional value but have the ability to modulate enzyme activity and exert a variety of bioactive effects on organisms (Câmara et al., 2020; Wang, Yang, et al., 2021). Numerous bioactive compounds, such as polyphenols, carotenoids, dietary fibers, unsaturated fatty acids, prebiotics, bioactive peptides, and vitamins, have been shown to have beneficial effects on the intervention of IBD (do Nascimento et al., 2021; Tie & Tan, 2022; Zhang et al., 2022). Utilizing food bioactive compounds for the prevention or treatment of IBD can help to circumvent the common adverse effects associated with conventional drug therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous bioactive compounds, such as polyphenols, carotenoids, dietary fibers, unsaturated fatty acids, prebiotics, bioactive peptides, and vitamins, have been shown to have beneficial effects on the intervention of IBD (do Nascimento et al, 2021;Zhang et al, 2022). Utilizing food bioactive compounds for the prevention or treatment of IBD can help to circumvent the common adverse effects associated with conventional drug therapy.…”

mentioning

confidence: 99%

An evaluation of animal models for using bioactive compounds in the treatment of inflammatory bowel disease

Tie,

Chen,

Tan

2024

Food Frontiers

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Inflammatory bowel disease (IBD) is a prevalent chronic relapsing‐remitting disease that affects the digestive tract and reduces patients’ quality of life. Food bioactive compounds are a promising approach for nutritional intervention of IBD with minimal side effects. To evaluate their potential, researchers have developed various animal models that simulate human IBD, including chemically induced, spontaneous, genetically engineered, and adoptive transfer models. In this work, the main animal models, pathogenesis, symptoms, strengths, and limitations of IBD were discussed. Although these models could not perfectly replicate human IBD, they provided useful tools to study the disease's progression and therapeutic processes. In addition, taking these IBD animals as models, the specific experimental methods, intervention results, and mechanisms of food bioactive compounds to prevent or treat IBD were described in detail. The continuous improvement of animal models is crucial to gain a better understanding of IBD's etiology and pathogenesis and to evaluate the efficacy of food bioactive compounds for the effective control of IBD.

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“…Pineapple ( Ananas comosus ) is a tropical plant whose edible fruit is one of the most important tropical fruits in the international trade market [ 63 , 64 ]. Tropical fruits such as pineapple juice and fruit have long been used as traditional treatments to cure digestion system discomforts [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

“…The antiinflammatory effect of bromelain is reported to be related to protease activity [ 69 , 70 ]. Bromelain has been shown to be beneficial both clinically and endoscopically in people with mild UC in clinical investigations [ 64 , 71 ].…”

Section: Introductionmentioning

confidence: 99%

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes

Şen¹

2022

Turkish Journal of Medical Sciences

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Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people have led to the application of complementary therapies due to the common belief that they are natural and safe, as well as due to the consideration of the side effect of current drugs. Curcumin, cannabinoids, wheatgrass, Boswellia, wormwood and Aloe vera are among the most commonly used complementary medicines in UC. However, these treatments may have adverse and toxic effects due to unintended interactions with drugs or drug-metabolizing enzymes such as cytochrome P450s; thus, being ignorant of these interactions might cause deleterious effects with severe consequences. In addition, the lack of complete and controlled long-term studies with the use of these complementary medicines regarding drug metabolism pose additional risk and unsafety. Thus, this review aims to give an overview of the potential interactions of drug-metabolizing enzymes with the complementary botanical medicines used in UC, drawing attention to possible adverse effects.

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Review on the potential application of non-phenolic compounds from native Latin American food byproducts in inflammatory bowel diseases

Cited by 19 publications

References 205 publications

Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism

Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism

An evaluation of animal models for using bioactive compounds in the treatment of inflammatory bowel disease

Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes

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