Review: Organotin compounds and their therapeutic potential: a report from the Organometallic Chemistry Department of the Free University of Brussels

Abstract

An overview of the development of antitumour organotin derivatives is presented and discussed for selected classes of compounds, such as tetraorganodicarboxylatodistannoxanes and related diorganotin dicarboxylates, and for triorganotin carboxylates. Among the carboxylate groups used are steroidcarboxylates and other biologically relevant carboxylates. High to very high in vitro activities have been found, sometimes equalling that of doxorubicin. Solubility in water is an important issue, dominating the in vivo testing of compounds. Polar substituents, like fluorine or polyoxaalkyl moieties, improve the water solubility. Although organotin derivatives constitute a separate class of compounds, the comparison with cisplatin is inevitable. Among the observed toxicities, neurotoxicity, known from platinum cytostatics, and gastrointestinal toxicity, typical for many oncology drugs, have been detected, but to a lower extent. Further research to develop novel useful organotin antitumour compounds needs to be carried out.

Synthesis, structural and spectral studies of five- and six-coordinate adducts of organotin(IV) halides containing dibenzylsulfoxide (dbso) as ligand. The crystal structures of fac-[MeSnCl3(dbso)2] and trans-[Ph2SnCl2(dbso)2]

“…It is interesting to compare our results with literature data for the five-coordinate adduct [Me 2 SnCl 2 (dbso)]. 5 In trans-[Ph 2 SnCl 2 (dbso) 2 ], the bond distance Sn1-O1 of 2.258(4) Å is significantly shorter than the equivalent bond distance value of 2.319 (10) 2 ], which has the chlorine atoms and the oxygen atoms cis, and the carbon atoms trans.…”

“…1,2 Insofar as many sulfoxides are also noteworthy for the same reasons, 3 a combination of the two chemistries is an interesting line to pursue. Diorganotin(IV) dihalides, and more particularly Me 2 SnCl 2 , form well-known 1:2 adducts with Lewis bases.…”

New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions: Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium

“…Organotin compounds have emerged as potential future pharmaceuticals as antitumor agents among nonplatinum chemotherapeutic metallopharmaceuticals in the last two decades [1][2][3][4][5]. Though tin-based drugs usually are less active than the corresponding platinum antitumor drugs, however, they have the advantage of lower toxicity [6].…”

The Effectiveness of Organotin (IV) Benzylisopropyldithiocarbamate Compounds as Insecticide Against <i>Aedes Aegypti</i> Linn (Diptera: Culicidae) in Laboratory

“…Among the biological activities of organotin (IV) compound have these compounds identified as a potential antiviral agent (Sreeja and Kurup, 2005), antineoplastic agents, antituberculosis (Gielen, 2002;Dokorou et al, 2004;Kovala-Demertzi et al, 2005;Kovala-Demertzi, 2006), antibacterial agent (Jamil et al, 2009), anticancer agent (Awang et al, 2010) and so on.…”