Review: radiolabeled polymers containing covalently bound<scp><sup>3</sup>H</scp>and<scp><sup>14</sup>C</scp>

Wolf, Jeremy R.

doi:10.1002/jlcr.3359

Cited by 7 publications

(3 citation statements)

References 81 publications

(77 reference statements)

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“…In vivo responses such as edema, bioresorption and deformation of the implant were observed through MRI [111]. Wolf extensively reviewed the radiolabeled polymers containing covalently bound 3 H and 14 C materials as benchmark tool for in vivo and in vitro studies for detection of polymer degradation, elucidation of mechanistic approach, bio-incorporation approach and drug delivery[115]. The extent of biodegradation was assessed by high-performance liquid chromatography (HPLC), mass spectrometry (MS) and 14 C radiolabel release.…”

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confidence: 99%

Controlled biodegradation of polymers using nanoparticles and its application

Kumar

Maiti

2016

RSC Adv.

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The disposal of non-degradable plastics is augmented exponentially as a result of poor recycling efficacy. The development of biodegradable plastics has become indispensable in last two decades because of its origin from renewable resources. The potential interest in biodegradable plastics involves eco-friendly obliteration via microbial action which transform into carbon dioxide and water resulting pollution free natural system. Even though its lucrative interest lies in multiple areas, some of the properties such as brittleness, poor thermal, mechanical and low gas barrier properties restrict their practical uses. Incorporation of nanoparticle in polymer matrix or by making nanocomposites overcomes the shortcomings of the biodegradable polymers. For further improving the aforementioned properties, several approaches have been utilized especially incorporation of nanoparticle in polymer matrix to prepare nanocomposites. One of the great advantages of nanoparticles is to tune the rate of biodegradation (both increase and decrease as compared to the rate of pure polymer) depending upon the need. Thus, chemical, physical and biological properties of the biodegradable polymers can be modified and controlled for sustainable application in medical and other areas. This review considers the major concerns about the type of biodegradable polyesters and their nanocomposites, great details about mechanism of biodegradation, factors influencing the biodegradation and their applications in biomedical and packaging industries.

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confidence: 99%

Controlled biodegradation of polymers using nanoparticles and its application

Kumar

Maiti

2016

RSC Adv.

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“…Radiolabeled materials have been shown to be a highly useful tool for other materials with significant analytical sensitivity challenges to enable studies at environmentally relevant concentrations, including polydimethylsiloxane (Kukkonen & Landrum, 1995;Tolle et al, 1995;Watts et al, 1995), polyacrylic acid (Larson et al, 1997), polyethylene glycol (Abdalla et al, 2005), and surfactant polymers, such as alcohol ethoxylates, alkyl ethoxy sulfates, and alkyl sulfates (Nuck & Federle, 1996;Steber & Wierich, 1985). Use of radiochemical labeling with 3H has been especially useful for quantifying exposure in several environmental polymer fate and effects studies as reported in the literature (Malik & Letey, 1991;Smith & Oehme, 1991;Wolf, 2016) and also in our laboratories (S. Belanger, Procter & Gamble FIGURE 3 Ratio of trophic sensitivities to cationic polymers. All ratios were constructed based on standard acute toxicity tests conducted using the same test material.…”

Section: Experimental Factors May Alter Observed Environmental Effectsmentioning

confidence: 99%

Environmental hazard of cationic polymers relevant in personal and consumer care products: A critical review

Connors

Arndt

Rawlings

et al. 2022

Integr Envir Assess & Manag

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Historically, polymers have been excluded from registration and evaluation under the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) program, the European chemical management program. Recently, interest has increased to include polymers. A tiered registration system has been envisioned and would begin with classes of polymers of greater interest based on certain properties. Cationic polymers are one such class. There is a pressing need to understand the quality and limitations of historical cationic polymer studies and to identify key sources of uncertainty in environmental hazard assessments so we can move toward scientifically robust analyses. To that end, we performed a critical review of the existing cationic polymer environmental effects literature to evaluate polymer characterization and test methodologies to understand how these parameters may affect test interpretation. The relationship between physicochemical parameters, acute and chronic toxicity, and relative trophic level sensitivity were explored. To advance our understanding of the environmental hazard and subsequent risk characterization of cationic polymers, there is a clear need for a consistent testing approach as many polymers are characterized as difficult-to-test substances. Experimental parameters such as dissolved organic carbon and solution renewal approaches can alter cationic polymer bioavailability and toxicity. It is recommended that OECD TG 23 "Aqueous-Phase Aquatic Toxicity Testing of Difficult Test Substances" testing considerations be applied when conducting environmental toxicity assays with cationic polymers.

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“…The detection of intact drug carriers inside the brain as well as carrier-drug dissociation monitoring through this type of techniques is still challenging and it is rarely shown. The use of radiolabelled polymers and/or drugs incorporating 14 C, and 3 H can contribute to this goal (Wolf, 2016).…”

Section: Additional Design Considerations and Strategiesmentioning

confidence: 99%

Envisioning the future of polymer therapeutics for brain disorders

Rodríguez-Otormín

Duro‐Castaño

Conejos‐Sánchez

et al. 2018

WIREs Nanomed Nanobiotechnol

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The growing incidence of brain‐related pathologies and the problems that undermine the development of efficient and effective treatments have prompted both researchers and the pharmaceutical industry to search for novel therapeutic alternatives. Polymer therapeutics (PT) display properties well suited to the treatment of neuro‐related disorders, which help to overcome the many hidden obstacles on the journey to the central nervous system (CNS). The inherent features of PT, derived from drug(s) conjugation, in parallel with the progress in synthesis and analytical methods, the increasing knowledge in molecular basis of diseases, and collected clinical data through the last four decades, have driven the translation from “bench to bedside” for various biomedical applications. However, since the approval of Gliadel® wafers, little progress has been made in the CNS field, even though brain targeting represents an ever‐growing challenge. A thorough assessment of the steps required for successful brain delivery via different administration routes and the consideration of the disease‐specific hallmarks are essential to progress in the field. Within this review, we hope to summarize the latest developments, successes, and failures and discuss considerations on designs and strategies for PT in the treatment of CNS disorders. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Review: radiolabeled polymers containing covalently bound³Hand¹⁴C

Cited by 7 publications

References 81 publications

Controlled biodegradation of polymers using nanoparticles and its application

Controlled biodegradation of polymers using nanoparticles and its application

Environmental hazard of cationic polymers relevant in personal and consumer care products: A critical review

Envisioning the future of polymer therapeutics for brain disorders

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Review: radiolabeled polymers containing covalently bound3Hand14C

Cited by 7 publications

References 81 publications

Controlled biodegradation of polymers using nanoparticles and its application

Controlled biodegradation of polymers using nanoparticles and its application

Environmental hazard of cationic polymers relevant in personal and consumer care products: A critical review

Envisioning the future of polymer therapeutics for brain disorders

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Product

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Review: radiolabeled polymers containing covalently bound³Hand¹⁴C