Review Scopoletin – A Coumarin Phytoalexin with Medicinal Properties

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

“…Scopoletin (6-methoxy-7-hydroxycoumarin) is reported from several plants, where it is possibly involved in protection against pathogens due to its antimicrobial properties [119]. This compound has been isolated from a mangrove endophytic strain of Penicillium sp., together with bergapten and umbelliferone (7-hydroxycoumarin) [120].…”

Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts

“…It contains scopoletin (7-hydroxy-6-methoxychromen-2-one), esculetin and so on. (Gnonlonfin et al 2012). In particular, scopoletin is originated from coumarin found in the root of plant.…”

Galanthamine, an anti-cholinesterase drug, effects plant growth and development inArtemisia tridentataNutt. via modulation of auxin and neurotransmitter signaling

“…Increased levels of scopoletin and scopolin have been shown to occur in response to stresses such as microbial attack, water stress, and wounding. 50 Furthermore, manipulation of cultures with growth regulators such as 2-4D, kinetin, salicylic acid, and methyl jasmonate was previously found to affect levels of these compounds, 50 most notably in tobacco cultures. [53][54][55] Although more enquiry is needed, our untargeted exploratory analysis has allowed us to formulate the hypothesis that cultures treated with galanthamine increase production of phenolic compounds.…”

“…Coumarins are a class of secondary metabolites derived from the shikamate pathway via phenylalanine and contribute to plant defense through their anti-fungal and anti-microbial properties. 50 Previous research identified coumarins, including scopoletin, isoscopoletin, esculin, esculetin, methylesculin, and umbelliferone, in leaf extracts of A. tridentata. 51,52 Our exploratory analysis found increasing amounts of scopoletin and its monoglucoside scopolin in response to galanthamine exposure.…”