Review – The impact of pharmacogenetics on the outcome of immune checkpoint inhibitors

de Joode, Karlijn; Heersche, Niels; Basak, Edwin A.; Bins, Sander; van der Veldt, Astrid A.M.; van Schaik, Ron H.N.; Mathijssen, Ron H.J.

doi:10.1016/j.ctrv.2023.102662

Cited by 1 publication

(1 citation statement)

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“…Due to variations in genetics, physiology, biochemistry, and other factors among different individuals, patients exhibit diverse responses to the same disease and the same drug treatment 171 , 172 . Some individuals might be highly sensitive to a particular medication, while others may show insensitivity or even severe side effects to the same drug 173 .…”

Section: St For Drug Researchmentioning

confidence: 99%

Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery

Cao,

Li,

Cui

et al. 2024

Theranostics

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Recent advancements in modern science have provided robust tools for drug discovery. The rapid development of transcriptome sequencing technologies has given rise to single-cell transcriptomics and single-nucleus transcriptomics, increasing the accuracy of sequencing and accelerating the drug discovery process. With the evolution of single-cell transcriptomics, spatial transcriptomics (ST) technology has emerged as a derivative approach. Spatial transcriptomics has emerged as a hot topic in the field of omics research in recent years; it not only provides information on gene expression levels but also offers spatial information on gene expression. This technology has shown tremendous potential in research on disease understanding and drug discovery. In this article, we introduce the analytical strategies of spatial transcriptomics and review its applications in novel target discovery and drug mechanism unravelling. Moreover, we discuss the current challenges and issues in this research field that need to be addressed. In conclusion, spatial transcriptomics offers a new perspective for drug discovery.

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Section: St For Drug Researchmentioning

confidence: 99%