Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl, Rudolf L.; Lehnert, Peter

doi:10.3109/00365529209000130

Cited by 9 publications

(6 citation statements)

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“…After intragastric application of a liquid meal, however, no correlation was found between the duodenal load of bile acids and plasma secretin concentrations (17). These data are in accordance with the hypothesis that bile and bile salts do not stimulate nutrient-induced pancreatic secretion (1).…”

Section: Gastroenteropancreatic Peptides With Stirnulatory Effectssupporting

confidence: 80%

“…In contrast to basal conditions, nutrient-induced pancreatic enzyme secretion is reduced by intraduodenal bile or bile salts in man, suggesting an impaired CCK release (1,30). In accordance with this hypothesis, Gomez et al (31) noted a significant decrease of plasma CCK-33/39 after oral ingestion of an amino acid solution when adding 6mmol of taurocholate.…”

Section: Gastroenteropancreatic Peptides With Stirnulatory Effectssupporting

confidence: 50%

“…Bile salts are the effective constituents of bile with regard to stimulation of basal pancreatic secretion (1). A solution of pure synthetic bile salts (20ml of a 50-mM solution), comparable to human gallbladder bile, increased plasma secretin levels significantly in man (13).…”

Section: Gastroenteropancreatic Peptides With Stirnulatory Effectsmentioning

confidence: 99%

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The Mediators of Bile Action on the Exocrine Pancreas

Riepl¹,

Lehnert²

1993

Scandinavian Journal of Gastroenterology

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Section: Gastroenteropancreatic Peptides With Stirnulatory Effectssupporting

confidence: 80%

Section: Gastroenteropancreatic Peptides With Stirnulatory Effectssupporting

confidence: 50%

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The Mediators of Bile Action on the Exocrine Pancreas

Riepl¹,

Lehnert²

1993

Scandinavian Journal of Gastroenterology

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“…application of 3 g bile in dogs. This discrepancy may be due to species differences and/or the different study design (26). In the latter experi- ments, pancreatic juice was not withdrawn from the duodenum.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man

Riepl¹,

Fiedler²,

Teufel³

et al. 1994

Pancreas

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Summary: Intraduodenal (i.d.) application of bile or Nataurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin. This study should show, whether vasoactive intestinal polypeptide (VIP), a partial agonist of secretin, may also be involved in the mediation of the hydrokinetic effect. Furthermore, plasma concentrations of somatostatin-like immunoreactivity (SLI) were measured in order to check whether this counterregulating hormone is also released by bile and TDC. Twenty investigations were carried out on 10 fasting healthy volunteers provided with a double-lumen Dreiling tube. Bile and TDC were intraduodenally applied in doses of 2-6 g and 200-600 mg, respectively, at 65-min intervals. Plasma samples were withdrawn at defined intervals for radioimmunological determination of VIP and SLI. Duodenal juice was collected in 10-min fractions and analyzed for volume, pH, bicarbonate, lipase, trypsin, and amylase. 1.d. application of bile or TDC dose dependently stimulated hydrokinetic and ecbolic pancreatic secretion. Bile exerted a slightly stronger effect than TDC. Pancreatic response was simultaneously accompanied by a significant increase of plasma VIP and SLI concentrations. The effect of bile on integrated plasma VIP and SLI concentrations seems to be dose dependent; the effect of TDC on integrated SLI, too. For the increase of integrated plasma VIP concentrations after TDC no doseresponse relation could be established. We conclude that VIP may be a further mediator of bile-induced volume and bicarbonate secretion. The release of plasma SLI indicates that inhibitory mechanisms concomitantly are triggered by i.d. bile and TDC, as already shown during digestion for the intestinal phase of pancreatic secretion. Key Words: Bile-Duodenum-Pancreatic secretionSomatostatin-Taurodeoxycholate-Vasoactive intestinal polypeptide.Intraduodenal (i.d.) application of bile or Nataurodeoxycholate (TDC) dose dependently enhances basal (1) and secretin-stimulated (2) hydrokinetic and ecbolic pancreatic secretion in man. The pancreatic response to i. d. bile (1,3,4) or bile salts (1,5,6) is accompanied by a release of secretin, the most important hormonal mediator of pancreatic volume and bicarbonate secretion (7-9).Vasoactive intestinal polypeptide (VIP) acts as a were not able to demonstrate a release of VIP in both portal and peripheral plasma after i.d. bile (3 g) in dogs. Therefore, one purpose of the present study was to investigate in man, whether VIP is dose dependently released by physiological loads of bile or TDC, a very effective bile salt with regard to pancreatic secretion (2).The intestinal phase of pancreatic secretion represents a net sum resulting from the responses to stimulatory and inhibitory mechanisms, as well (13). As we previously showed in man (l), i.d. ap- 209

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“…The purpose of the present study was to elucidate the relationship between duodenal acidification, secretin and hepatic biliary bicarbonate secretion in the conscious pig. As bile salts may stimulate the release of secretin (Riepel & Lehnert 1992), an experiment in which bile was diverted from the duodenum was included.…”

mentioning

confidence: 99%

Regulation of porcine biliary secretion by secretin

Sætre

Andersen

Houe

et al. 1998

Acta Physiologica Scandinavica

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The importance of physiological plasma levels of secretin in biliary bicarbonate secretion is not known. However, in anaesthetized pigs the substantial hepatic output of bicarbonate into the duodenum in response to low doses of secretin exceeds pancreatic bicarbonate output. The aim was therefore to study the relationship between duodenal acidification, secretin and hepatic biliary bicarbonate output in the conscious pig. Göttingen minipigs (n = 22) were cholecystectomized and the common bile duct catheterized. The biliary bicarbonate secretion in response to intraduodenal HCl, secretin or pentagastrin given intravenously, and to meal was studied. Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly. The secretin response to acidification was sufficient to explain the subsequent increase in biliary bicarbonate secretion. Hepatic bicarbonate secretion and concentrations of CCK and secretin in plasma increased postprandially. Exclusion of bile salts from the duodenum abolished postprandial increase in bile volume and increased release of CCK in fasting and fed pigs whereas secretin release was diminished. The results demonstrate that hepatic bicarbonate secretion is stimulated by endogenous secretin and therefore may have a physiological role in duodenal neutralization.

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Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Cited by 9 publications

References 59 publications

The Mediators of Bile Action on the Exocrine Pancreas

The Mediators of Bile Action on the Exocrine Pancreas

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man

Regulation of porcine biliary secretion by secretin

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