Review: The vascular system and erectile dysfunction in diabetes — the role of penile Doppler

Jones, R; Gingell, J. C.

doi:10.1177/14746514020020040401

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…In contrast, the 69.3% is higher than the 37% reported among Hong Kong diabetic men [ 19 ] and the 63.6% reported among Chinese diabetic men [ 24 ] but agrees with the 20% to 85% incidence rate for diabetic subjects [ 18 , 20 , 21 ] reported in other studies. This wide variation in the incidence of SD could be due in part to the definition used for SD, the period of data retrieval, the population surveyed, the setting in which the patients were studied, the manner in which the participants were questioned, the number and selection of participants, cultural background, socioeconomic level, quality of psychosexual relationships and income.…”

Section: Discussionsupporting

confidence: 87%

“…Reduced sexual function is a well-documented complication of diabetes. Previous reports have shown that diabetic men are at increased risk for SD at an earlier age [ 7 , 8 , 18 , 19 ], with an incidence ranging from 20% to 85% [ 18 , 20 , 21 ]. Most of the risk factors for SD (such as vascular disease, hypertension, peripheral neuropathy and obesity) overlap with many of the comorbidities linked with diabetes with prevalence and severity being more common in people with diabetes than in the general population [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Determinants of sexual dysfunction among clinically diagnosed diabetic patients

Owiredu

Amidu

Alidu

et al. 2011

Reprod Biol Endocrinol

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BackgroundDiabetes mellitus is a chronic disease that can result in various medical, psychological and sexual dysfunctions (SD) if not properly managed. SD in men is a common under-appreciated complication of diabetes. This study assessed the prevalence and determinants of SD among diabetic patients in Tema, Greater Accra Region of Ghana.MethodSexual functioning was determined in 300 consecutive diabetic men (age range: 18-82 years) visiting the diabetic clinic of Tema General Hospital with the Golombok Rust Inventory of Sexual Satisfaction (GRISS) questionnaire, between November, 2010 and March, 2011. In addition to the socio-demographic characteristics of the participants, the level of glycosylated haemoglobin, fasting blood sugar (FBS) and serum testosterone were assessed. All the men had a steady heterosexual relationship for at least 2 years before enrolment in the study.ResultsOut the 300 participants contacted, the response rate was 91.3% after 20 declined participation and 6 incomplete data were excluded All the respondents had at least basic education, 97.4% were married, 65.3% were known hypertensive, 3.3% smoked cigarettes, 27% took alcoholic beverages and 32.8% did some form of exercise. The 69.3% SD rate observed in this study appears to be related to infrequency (79.2%), non-sensuality (74.5%), dissatisfaction with sexual acts (71.9%), non-communication (70.8%) and impotence (67.9%). Other areas of sexual function, including premature ejaculation (56.6%) and avoidance (42.7%) were also substantially affected. However, severe SD was seen in only 4.7% of the studied population. The perceived "adequate", "desirable", "too short" and "too long intra-vaginal ejaculatory latency time (IELT) are 5-10, 5-10, 1-2 and 15-30 minutes respectively. Testosterone correlates negatively with glycated haemoglobin (HBA1c), FBS, perceived desirable, too short IELT, and weight as well as waist circumference.ConclusionSD rate from this study is high but similar to that reported among self-reported diabetic patients in Kumasi, Ghana and vary according to the condition and age. The determinants of SD from this study are income level, exercise, obesity, higher perception of "desirable" and "too short" IELT.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Determinants of sexual dysfunction among clinically diagnosed diabetic patients

Owiredu

Amidu

Alidu

et al. 2011

Reprod Biol Endocrinol

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“…Diabetic vasculopathy including micro‐ and macro‐angiopathy, and endothelial dysfunction plays a major role in causing ED in DM by inducing atherosclerotic changes with a decrease in penile blood flow which is a key factor in vascular ED (Esposito et al, ; Giuliano, Leriche, Jaudinot, & Gendre, ). PPDU is the most widely used investigation to diagnose vascular induced ED, but it is an invasive and expensive (Jones & gingell, ).…”

Section: Discussionmentioning

confidence: 99%

Platelet Indices as a marker for early prediction of erectile dysfunction in diabetic patients

et al. 2018

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Erectile dysfunction is one of the major concerns in diabetic patients. Platelet Indices including mean platelet volume, platelet count and platelet distribution width are important biomarkers for platelet activation and pathophysiology of atherothrombosis. Measurement of Platelet Indices may early predict erectile dysfunction in diabetic men. This study aimed to measure Platelet Indices in diabetic patients with erectile dysfunction and to correlate between them and erectile dysfunction especially of vasculogenic type. The study included 30 diabetic patients with diagnosed erectile dysfunction and 20 normal males as a control. Each patient was evaluated by history, International Index of Erectile Function-5, general and local examination, HbA1c, pharmaco-penile duplex ultrasonography and blood sample to measure Platelet Indices. Platelet distribution width and mean platelet volume were significantly higher in patients than controls (p < 0.001). Their levels were significantly higher in vasculogenic erectile dysfunction than other types (p < 0.001). No statistically significant association regards the platelet count (p > 0.05). We concluded that Platelet Indices are high in diabetic patients with erectile dysfunction especially those with vasculogenic aetiology. They can predict erectile dysfunction in diabetic men early, and so they may be considered as cheap, available and useful biomarker for early diagnosis of vasculogenic erectile dysfunction in diabetic patients. K E Y W O R D Sdiabetes, erectile dysfunction, Platelet Indices

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“…8 PPDU is the most commonly used examination for the diagnosis of vascular induced ED, but it is invasive and costly. 19 Previous studies assumed that platelet and leukocyte adhesion has an adverse impact on erection through the release of vasoconstrictor substances and reactive oxygen species, and this could also play a part in the ED progress. 20 PIs are popular indicators that are used to evaluate the activity and function of platelets.…”

Section: Discussionmentioning

confidence: 99%