Review Use of Tisseel, a Fibrin Sealant, for Particulate Graft Stabilization

Rechtin, Michael; Broccoli, Nicholas; Krishnan, Deepak G.; Phero, James A.

doi:10.1016/j.joms.2020.07.022

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Cucchi A. et al [32][33][34][35] carried out a series of studies comparing the use of dPTFE membranes to titanium meshes, in which the percentages of complications of PTFE membranes varied from 12 to 15%, while conventional titanium meshes or customized CAD-CAM meshes associated with the use of resorbable membranes showed percentages of complications varying between 4 and 33%.…”

Section: Discussionmentioning

confidence: 99%

Restoration of Severe Bone and Soft Tissue Atrophy by Means of a Xenogenic Bone Sheet (Flex Cortical Sheet): A Case Report

Rossi¹,

Memé

Strappa

et al. 2023

Applied Sciences

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The use of xenogenic cortical bone laminas in Guided Bone Regeneration (GBR) has been well described in the literature over the past decade. These biomaterials present a very low degree of complications due to their nature (porcine or equine collagenated bone) and the fact that when they become exposed, they simply hydrolyze without major complications. One of the problems related to the first generation of these laminas was their extreme rigidity and return elasticity, often forcing clinicians to anchor them with pins and/or screws. A new generation of bone laminas called Flex Cortical Sheet (FCS) have recently been introduced with machine-made thicknesses of 0.2, 0.5, and 0.9 mm and increased flexibility and adaptability to ridge defects. This paper has the goal of presenting a case of vertical and horizontal reconstruction performed by means of a 0.5 mm FCS and showing the workflow necessary to successfully restore a complex situation. After 8 months of healing, the GBR resulted in a horizontal and vertical augmentation of 8 mm and 8 mm, respectively. The radiographic examination at 18 months demonstrated great stability of new bone around implants.

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Section: Discussionmentioning

confidence: 99%

Restoration of Severe Bone and Soft Tissue Atrophy by Means of a Xenogenic Bone Sheet (Flex Cortical Sheet): A Case Report

Rossi¹,

Memé

Strappa

et al. 2023

Applied Sciences

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“…In addition, the scientific literature reports numerous intrinsic characteristics of these materials directly correlated with the mechanism of action in the bone regeneration process, suggesting, when associated, the formation of a tissue construction with synergistic effects [ 16 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] ( Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

Use of Photobiomodulation Combined with Fibrin Sealant and Bone Substitute Improving the Bone Repair of Critical Defects

et al. 2022

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In this preclinical protocol, an adjunct method is used in an attempt to overcome the limitations of conventional therapeutic approaches applied to bone repair of large bone defects filled with scaffolds. Thus, we evaluate the effects of photobiomodulation therapy (PBMT) on the bone repair process on defects filled with demineralized bovine bone (B) and fibrin sealant (T). The groups were BC (blood clot), BT (B + T), BCP (BC + PBMT), and BTP (B + T + PBMT). Microtomographically, BC and BCP presented a hypodense cavity with hyperdense regions adjacent to the border of the wound, with a slight increase at 42 days. BT and BTP presented discrete hyperdensing areas at the border and around the B particles. Quantitatively, BCP and BTP (16.96 ± 4.38; 17.37 ± 4.38) showed higher mean bone density volume in relation to BC and BT (14.42 ± 3.66; 13.44 ± 3.88). Histologically, BC and BCP presented deposition of immature bone at the periphery and at 42 days new bone tissue became lamellar with organized total collagen fibers. BT and BTP showed inflammatory infiltrate along the particles, but at 42 days, it was resolved, mainly in BTP. In the birefringence analysis, BT and BTP, the percentage of red birefringence increased (9.14% to 20.98% and 7.21% to 27.57%, respectively), but green birefringence was similar in relation to 14 days (3.3% to 3.5% and 3.5% to 4.2%, respectively). The number of osteocytes in the neoformed bone matrix proportionally reduced in all evaluated groups. Immunostaining of bone morphogenetic protein (BMP—2/4), osteocalcin (OCN), and vascular endothelial growth factor (VEGF) were higher in BCP and BTP when compared to the BC and BT groups (p < 0.05). An increased number of TRAP positive cells (tartrate resistant acid phosphatase) was observed in BT and BTP. We conclude that PBMT positively influenced the repair of bone defects filled with B and T.

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Polyurethane‐Based Bioglue for the Repair of Arterial Ruptures

Wu,

Xuan,

Jiang

et al. 2024

Adv Funct Materials

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A bioglue with fast blood absorption and strong adhesion, capable of stopping bleeding through physical blockage rather than coagulation, is imperative for treating arterial hematorrhea during surgery and in wilderness first aid. Here, we developed a two‐component polyurethane‐based arterial glue (PAG). The key strategy of this work is to optimize the hydrophilicity and crosslinking density of the bioglue by modulating the proportion of hydrophilic polyethylene glycol (PEG)‐based urethane prepolymer, the hydrophobicamine crosslinkers, and the functionality of the crosslinkers. Compared with commercial PEG‐based bioglue, PAG has a similar water absorption rate but less swelling. Furthermore, owing to the hydrogen bonding originating from the urethane/urea bonds and extracovalent bond formation with tissue, PAG showed ≈2 times greater adhesive strength than commercial PEG‐based bioglues. In addition, PAG has good hemocompatibility and maintains cured integrity even under circulating blood flushing conditions, thereby reducing the risk of arterial embolism. This bioglue demonstrated a more reliable sealing effect with a higher survival rate compared to commercial fibrin and PEG‐based bioglues on the rat abdominal aorta and rabbit carotid artery in open operations; moreover, it can be assembled into a commercial balloon dilation catheter system, enabling minimally invasive surgeries on the porcine femoral artery.

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Review Use of Tisseel, a Fibrin Sealant, for Particulate Graft Stabilization

Cited by 6 publications

References 3 publications

Restoration of Severe Bone and Soft Tissue Atrophy by Means of a Xenogenic Bone Sheet (Flex Cortical Sheet): A Case Report

Restoration of Severe Bone and Soft Tissue Atrophy by Means of a Xenogenic Bone Sheet (Flex Cortical Sheet): A Case Report

Use of Photobiomodulation Combined with Fibrin Sealant and Bone Substitute Improving the Bone Repair of Critical Defects

Polyurethane‐Based Bioglue for the Repair of Arterial Ruptures

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