Reviewing acute hip fractures in adults

Abstract

Hip fractures are considered a significant public health issue, representing a substantial burden on our healthcare system and society. They are one of the leading causes of disability among older adults, especially women. Globally, an estimated 18% of women and 6% of men will be affected by hip fractures at some time in life. Hip fractures are a major cause of long-term disability among older adults and more significant than mortality, as only 60% of patients regain their preinjury level of mobility. This has detrimental effects on quality of life and activities of daily living, imposing a level of dependence that has personal, social, and systemic consequences.

Human umbilical cord mesenchymal stromal cells promotes the proliferation and osteogenic differentiation of autologous bone marrow stem cells by secreting exosomes

“…Because senior victims of hip fractures develop multiple chronic diseases plus the weakened body organ functions, they are prone to various perioperative complications, which increase the surgical risks. Even if the perioperative period is safely passed, only some patients succeed in recovering to the pre-operative functions [ 33 , 34 ]. Our current research provides effective evidence for the first time to prove that exogenous stem cells and host endogenous progenitor cells make communications through intercellular exosomal signals, which improves cell proliferation and osteogenic differentiation in vitro, and this information may help to develop a new acellular bone healing therapy in the future.…”

Older adults and vitamin D hip fracture connections-what is the 2022 research base indicating?

“…it also appears that more might be done to translate what is shown into practice on an individualized basis in the context of post fracture preventive efforts in light of the immense importance of reducing the prevalence of second or third hip fractures, 46 and mortality rates 47 along with higher rates of disability than those cases experiencing single hip fractures, which alone is substantive. 48 Needed in terms of research however, are both consortia as well as funders willing to support the desired magnitude and scope of effort required to ensure success, including the use of some agreed upon standard procedures, sampling strategies, and outcome measures, plus long term follow up studies of well defined samples of hip fracture subgroups of various ages, and of various degrees of health, located in diverse geographic, institutional, community and cultural venues and locations. Until then, and in light of the growing number of older adults worldwide, and the fact that many already suffer from multiple health issues and frailty as well as obesity and bone fragility, hip fracture prevalence rates are yet more likely to rise, rather than fall over time, even though pharmacologic strategies have yielded some protective benefits for some time.…”

Association between Patient Activation Level and Functional Outcomes in Older Adults with Hip Fractures

“…The score is determined during the pre-surgery evaluation and based on the patient's comorbidities. It is a 5-point ordinal scale, but for this study, it has been classified into low (Barry & Maday, 2021;Dyer et al, 2021) or high (Gamvrili et al, 2022;McDonough et al, 2021;Veronese & Maggi, 2018) categories (Hackett et al, 2015).…”

“…Hip fractures are a common cause of disability among older adults, and this problem is expected to increase worldwide as the population ages (Barry & Maday, 2021). The impact of these fractures on functionality, mortality, and healthcare costs is significant, highlighting the need for effective rehabilitation (Dyer et al, 2021;McDonough et al, 2021;Veronese & Maggi, 2018).…”