Reviewing the Available Herbal Resources for Treating Psoriasis: Safe and Alternative Way for Therapeutics

Dongare, Shruti; Shende, Vaibhav; Mahapatra, Debarshi Kar

doi:10.1201/9781003054894-5

Cited by 1 publication

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“…Topical treatments offer various advantages over oral delivery. The pharmacokinetics are based on skin absorption, which avoids substantial first-pass metabolism and allows for immediate access and localisation to the site of action (26,27) . Shikov et al (28) studied the pharmacokinetics of Fucus vesiculosus fucoidans following topical administration.…”

Section: Discussionmentioning

confidence: 99%

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

Bhuvaneshwari,

Chitra,

Vidya

et al. 2023

IJST

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Objectives: To validate the pharmacokinetic effects of the bioactive constituents present in green marine algae Valoniopsis pachynema for treating Psoriasis by in silco methods. Methods: The green marine macroalga was collected from the coastal areas of Ramanathapuram, Tamil Nadu and it was confirmed as Valoniopsis pachynema by the CSIR-Central Marine Algal Research Station, Ramanathapuram. The GC-MS analysis of the algal extract revealed the presence of 7 different functional compounds and these ligands molecules were used for molecular docking studies with TNF-α, which is majorly involved in causing Psoriasis. The ADME Predictions of 7 compounds were computed by SwissADME and PreADMET tools. The physico-chemical properties and druglikeness predictions of the compounds 1-7 were analysed by Molinspiration. The Molecular Docking scores and the residual amino acid interactions of 7 compounds against crystal structure of TNF-α (2AZ5) binding domain were analysed by Autodock Vina. Findings : The potential functional compounds present in the algal extract were found to be Cycloartenol (CAL), Eicosane (ESN), Phytol (PTL), Cis-13 Eicosenoic acid (CEA), Octadecanoic acid (ODA), Squalene (SQL) and Neophytadiene (NPN). The pharmacokinetic properties and docking studies of all 7 different ligands revealed Cycloartenol as the effective ligand having inhibitor constant 3.05µM and binding energy of -7.52 kcal/mol against TNF-α and it was found to interact with the amino acids ILE 136 and PRO 139 present in the active site domain of the protein. According to the in silico studies, the active component (Cycloartenol (CAL) in Valoniopsis pachynema reduces the amount of tumour necrosis factor which is produced in chronic skin inflammation. Thus, the seaweed metabolites were found to be the promising candidates https://www.indjst.org/ 4339

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Section: Discussionmentioning

confidence: 99%