Using herbal resources for medicinal purposes has persisted across diverse cultures, harnessing potential bioactivities. Despite the availability of commercial drugs, populations, including those in Mexico, continue to integrate herbal medicine into their healthcare practices. This study on Hermosillo, city in Northwest Mexico, exploring the prevalence and patterns of herbal medicine use. A cross-sectional study was conducted from May to September 2023, surveying 441 residents through a structured questionnaire. Demographic characteristics, awareness, and experiences with herbal medicine were assessed. Most participants were female (67.57 %), aged 30 years old or younger (67.57 %), and urban residents (90.70 %). The family was the primary source of knowledge for herbal medicine (73.92 %), emphasizing cultural continuity. Most participants (93.65 %) used herbal medicine when regarded as necessary, with 57.59 % reporting partial success. Despite reservations about safety (41.59 %), concurrent use with conventional treatments was common. The study underscores the persistent cultural connection to herbal medicine in Mexican families. Awareness campaigns emphasizing responsible herbal medicine use, especially in vulnerable groups, are crucial. The findings contribute to a broader understanding of herbal medicine trends and practices, emphasizing the importance of local perspectives.