2017
DOI: 10.1111/resp.13140
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Reviewing the relationship between OSA and cognition: Where do we go from here?

Abstract: Obstructive sleep apnoea (OSA) is a disorder of breathing during sleep resulting in temporary reduction in cerebral oxygenation and sleep disruption. A growing body of research reveals a relatively consistent pattern of deficits in cognition, particularly in attention, episodic memory, and executive function, which are partially remediated by treatment. This is where the consensus ends. Despite a number of competing explanations regarding how OSA affects cognition, reliable evidence is hard to find, which may … Show more

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Cited by 119 publications
(117 citation statements)
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References 97 publications
(139 reference statements)
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“…These co‐morbidities affect healthcare utilization and are associated with poorer clinical outcomes . The concurrence of OSA with various neurocognitive and mental health issues can worsen outcomes compared with experiencing either condition in isolation . Similar worsening of outcomes has been reported with the overlap of OSA and obstructive lung disease (overlap syndrome) .…”
Section: Sleepmentioning
confidence: 84%
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“…These co‐morbidities affect healthcare utilization and are associated with poorer clinical outcomes . The concurrence of OSA with various neurocognitive and mental health issues can worsen outcomes compared with experiencing either condition in isolation . Similar worsening of outcomes has been reported with the overlap of OSA and obstructive lung disease (overlap syndrome) .…”
Section: Sleepmentioning
confidence: 84%
“…Mounting evidence demonstrates the complex interactions between OSA and other co‐morbid conditions . These co‐morbidities affect healthcare utilization and are associated with poorer clinical outcomes .…”
Section: Sleepmentioning
confidence: 99%
“…Our sets of results converge on a single conclusion, that OSA instigates an acute neuroinflammatory response in the basal forebrain, and more chronically in other parts of frontal cortex, which consequently leads to a true network-specific structural changes with functional and further metabolic alterations. Patients with OSA are known to be prone to obesity (28), they have well documented cognitive and neuropsychiatric deficits (24), excessive daytime somnolence, and are more likely to develop depression and anxiety. (3,24,29) They are also known to be particularly prone to traffic and general work accidents, in part through their welldocumented deficits in attention (24), but also presumably through the erroneous encoding of spatial information in the context of navigation.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with OSA are known to be prone to obesity (28), they have well documented cognitive and neuropsychiatric deficits (24), excessive daytime somnolence, and are more likely to develop depression and anxiety. (3,24,29) They are also known to be particularly prone to traffic and general work accidents, in part through their welldocumented deficits in attention (24), but also presumably through the erroneous encoding of spatial information in the context of navigation. (2, 30) Somewhat surprisingly, our data suggested an early antidepressogenic effect of the neuroinflammatory response in OSA that is TLR2-dependent, and which is functionally linked to a distinct fronto-brainstem subcircuitry.…”
Section: Discussionmentioning
confidence: 99%
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