Reviewing the reliability, effectiveness and applications of Licox in traumatic brain injury

Keddie, Stephen; Rohman, Lebur

doi:10.1111/j.1478-5153.2012.00499.x

Cited by 13 publications

(11 citation statements)

References 54 publications

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“…For sensors calibrated in vitro then implanted, the matrix of the calibration solution should reflect that of the in vivo matrix. Keddie and Rohman noted that differences between the calibration solution and in vivo test environment most assuredly cause the probe to function “differently” . The main differences between in vivo and in vitro calibrations are: the mass transport through a standard solution is different due to diffusion and convection, there are numerous interferences from a complex sample matrix in vivo, causing the limited operational stability of sensors in biological media .…”

Section: Resultsmentioning

confidence: 95%

Long–term Drifts in Sensitivity Caused by Biofouling of an Amperometric Oxygen Sensor

et al. 2016

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Changes in oxygen sensitivity of an poly(o‐phenylenediamine) (PoPD) coated gold electrode was determined by constructing calibration curves in vitro. Oxygen sensitivities recorded in the presence of biofoulants were significantly different from those recorded in buffer; however, PoPD demonstrated its effectiveness in providing some resistance to changes in oxygen sensitivity over time compared to a bare electrode. Three sets of PoPD‐coated electrodes were calibrated in simple electrolyte of phosphate buffered saline; each set yielding an average oxygen sensitivity of 0.58±0.03 μA/ppm, 0.68±0.01 μA/ppm, and 0.48±0.01 μA/ppm (n=4), which shows the electrode to electrode variation in the PoPD‐coating/electrode. These sets were correspondingly exposed to bovine serum albumin, fibrinogen, rat brain homogenate. Exposure to these biofoulants resulted in decreases in sensitivity ranging from 26–35 % after immediate exposure. Furthermore, long‐term exposure to some biofoulants causes significant decreases in sensitivity over a time period of 14 days. We also estimated through in vitro exposure to rat brain homogenate the errors that might be associated with current methods of calibration. Sensitivities to oxygen determined by precalibration resulted in a 50 % error from the sensitivity found in vitro; the error from postcalibration after rinsing resulted in 25 % error.

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Section: Resultsmentioning

confidence: 95%

Long–term Drifts in Sensitivity Caused by Biofouling of an Amperometric Oxygen Sensor

et al. 2016

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“…Oxygen tension monitoring is used for several purposes in clinical practice, especially in neurosurgery and neuroanesthesia for the monitoring of brain oxygenation during the treatment of traumatic injuries, cerebral aneurisms, and other neurological conditions (Cerejo, Silva, Dias, & Vaz, ; Cyrous, O'Neal, & Freeman, ; Gelabert‐Gonzalez, Fernandez‐Villa, & Ginesta‐Galan, ; Keddie & Rohman, ). It has also been used for experimental purposes to determine the correlation between renal blood flow and tissue oxygenation at different intra‐abdominal pressures (Wiesenthal et al, ).…”

Section: Discussionmentioning

confidence: 99%

Flap monitoring with continuous oxygen partial tension measurement in breast reconstructive surgery: A preliminary report

et al. 2017

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“…In the past decade several studies showed a correlation between low brain oxygen levels and higher mortality rate and unfavorable outcome [ 182 , 183 ]. Combined monitoring of ICP and brain tissue oxygen tension has shown to be superior to ICP alone [ 184 , 185 ]. Additionally, brain oxygenation offers a new variable to evaluate cerebral autoregulation and cerebrovascular reactivity as mentioned before in Table 3 .…”

Section: Neuromonitoring After Tbimentioning

confidence: 99%

What’s New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment

Reis

Wang

Akyol

et al. 2015

IJMS

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Traumatic brain injury (TBI), defined as an alteration in brain functions caused by an external force, is responsible for high morbidity and mortality around the world. It is important to identify and treat TBI victims as early as possible. Tracking and monitoring TBI with neuroimaging technologies, including functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and high definition fiber tracking (HDFT) show increasing sensitivity and specificity. Classical electrophysiological monitoring, together with newly established brain-on-chip, cerebral microdialysis techniques, both benefit TBI. First generation molecular biomarkers, based on genomic and proteomic changes following TBI, have proven effective and economical. It is conceivable that TBI-specific biomarkers will be developed with the combination of systems biology and bioinformation strategies. Advances in treatment of TBI include stem cell-based and nanotechnology-based therapy, physical and pharmaceutical interventions and also new use in TBI for approved drugs which all present favorable promise in preventing and reversing TBI.

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Reviewing the reliability, effectiveness and applications of Licox in traumatic brain injury

Cited by 13 publications

References 54 publications

Long–term Drifts in Sensitivity Caused by Biofouling of an Amperometric Oxygen Sensor

Long–term Drifts in Sensitivity Caused by Biofouling of an Amperometric Oxygen Sensor

Flap monitoring with continuous oxygen partial tension measurement in breast reconstructive surgery: A preliminary report

What’s New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment

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