Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

Minati, Ludovico; Edginton, Trudi; Bruzzone, Maria Grazia; Giaccone, Giorgio

doi:10.1177/1533317508328602

Cited by 237 publications

(190 citation statements)

References 311 publications

(361 reference statements)

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“…Alzheimer's patients' loss of language and so-called "failure" of communication is well documented in the scientific community (Verma and Howard 2012;Minati et al 2009), and has been explored both in terms of verbal fluency and naming (Chan et al 1991;Auriacombe et al 2006;Laws et al 2007;Apostolova et al 2008;Taler and Phillips 2008) as well as semantic fluency (Adlam et al 2006;Clark et al 2009). This literature identifies language impairment, including principal deficits in naming and fluency, as the prognostic marker of early stages of AD.…”

Section: Intertextualizing Sciencementioning

confidence: 99%

Anamnesis: Intertextual Memory and Alzheimer’s Disease

Wagner

2017

Genealogy

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This essay develops and performs a theory of intertextual memory; and uses this concept as a heuristic to re-conceptualize identity for people suffering from Alzheimer's disease. This work emerges from three key sites of personal and cultural inquiry. At the center is my engagement with my matrilineal ancestry; which is haunted by the specter of memory loss: my mother's mother (my Nanny) was diagnosed with Alzheimer's disease (AD) in 2002 when she was 73; and my mother was diagnosed with Early Onset Alzheimer's in 2012 when she was 51. By telling stories about my mother and my Nanny which rely on intertextual memory; I hope to broaden the poetic space of remembering and to challenge the Western humanistic conception of identity as inherent; atomistic; and highly dependent on successful memory performance. Secondly; I examine the rhetorical discourse circulating Alzheimer's disease in the popular cultural imaginary; where illness metaphors deleteriously situate the forgetting body within narratives of failure; fear; and loss of personhood. I argue that an intertextual approach to memory performance can help us reimagine Alzheimer's patients outside the stigmatizing parameters of these broader cultural stories. Lastly; I draw on empirical research related to communication failure in AD in order to consider the ways caregivers might approach Alzheimer's patients with the kind of linguistic and interactional flexibility subtended by an intertextual approach to identity; in order to forge improved relationships both with Alzheimer's patients and with the disease itself.

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Section: Intertextualizing Sciencementioning

confidence: 99%

Anamnesis: Intertextual Memory and Alzheimer’s Disease

Wagner

2017

Genealogy

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“…Although PET produces images with higher resolution, SPECT is considered to be adequate to detect abnormalities of perfusion which are specific for AD (e.g., Caroli et al (2007); Herholz et al (2002b); Ishii et al (1999);Matsuda (2007)). As SPECT is -in comparison to PET -more prevalent and economical, it is commonly the preferred imaging method according to Minati et al (2009).…”

Section: Constitution Of the Data Matrixmentioning

confidence: 99%

Principal Component Analysis Applied to SPECT and PET Data of Dementia Patients – A Review

Stühler¹,

Merhof²

2012

Principal Component Analysis - Multidisciplinary Applications

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“…Alzheimer's disease (AD) is the most prevalent cause of dementia, a neurodegenerative condition which generally affects people over 65 years old (Minati, Edginton, Bruzzone, & Giaccone, 2009). Although it is impossible to know which individuals will develop AD, some genetic mutations induce the early onset of the disease (Bertram & Tanzi, 2011) helping to follow the evolution of the symptoms and the physiological changes in early stages of the disease.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers identification in Alzheimer’s disease using effective connectivity analysis from electroencephalography recordings

et al. 2016

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Alzheimer's disease (AD) is the most common cause of dementia, which generally affects people over 65 years old. Some genetic mutations induce early onset of AD and help to track the evolution of the symptoms and the physiological changes at different stages of the disease. In Colombia there is a large family group with the PSEN1 E280A mutation with a median age of 46,8 years old for onset of symptoms. AD has been defined as a disconnection syndrome; consequently, network approaches could help to capture different features of the disease. The aim of the current work is to identify a biomarker in AD that helps in the tracking of the neurodegenerative process. Electroencephalography (EEG) was recorded during the encoding of visual information for four groups of individuals: asymptomatic and mild cognitive impairment carriers of the PSEN1 E280A mutation, and two non-carrier control groups. For each individual, the effective connectivity was estimated using the direct Directed Transfer Function and three measurements from graph theory were extracted: input strength, output strength and total strength. A relation between the cognitive status and age of the participants with the connectivity features was calculated. For those connectivity measures in which there is a relation with the age or the clinical scale, the performance as a diagnostic feature was evaluated. We found that output strength connectivity in the right occipito-parietal region is related to age of the carrier groups (r = −0,54, p = 0,0036) and has a high sensitivity and high specificity to distinguish between carriers and non-carriers (67 % sensitivity and 80 % specificity in asymptomatic cases, and 83 % sensitivity and 67 % specificity in symptomatic cases). This relationship indicates that output strength connectivity could be related to the neurodegenerative process of the disease and could help to track the conversion from the asymptomatic stage to dementia.Keywords: Familial Alzheimer disease, electroencephalography, effective connectivity, brain graphs. RESUMENLa enfermedad de Alzheimer (EA) es la causa más común de demencia, la cual afecta generalmente a personas después de los 65 años de edad. Algunas mutaciones genéticas inducen la aparición temprana de EA ayudando a monitorear la evolución de los síntomas y los cambios fisiológicos en diferentes etapas de la enfermedad. En Colombia existe un gran grupo familiar con la mutación PSEN1 E280A, con una edad media de aparición de los síntomas de 46,8 años. La EA ha sido definida como un síndrome de desconexión; en consecuencia, enfoques de redes podrían ayudar a capturar diferentes características de la enfermedad. El objetivo del presente trabajo es identificar un biomarcador en la EA que permita realizar el seguimiento del proceso neurodegenerativo. Se registró una electroencefalografía (EEG) durante la codificación de información visual en cuatro grupos de sujetos: portadores de la mutación PSEN1 E280A asintomáticos y con deterioro cognitivo leve y dos grupos control de no portadores. ...

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Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

Cited by 237 publications

References 311 publications

Anamnesis: Intertextual Memory and Alzheimer’s Disease

Anamnesis: Intertextual Memory and Alzheimer’s Disease

Principal Component Analysis Applied to SPECT and PET Data of Dementia Patients – A Review

Biomarkers identification in Alzheimer’s disease using effective connectivity analysis from electroencephalography recordings

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