The authors study the publication profiles of articles relating to the musculoskeletal system in two indexed Brazilian general medical journals registered in PUBMED, over a period of two years. They selected 67 articles with heterogeneous distribution between the journals studied, and observed clear progression in the number of articles between the years studied in both publications, especially in Clinics. Among the areas of interest, the articles referring to surgery, clinical approaches and biomechanical studies had significant presence in Clinics. In RAMB, the studies were focused exclusively on the area of clinical interest. As regards design, clinical trials, reviews and case series predominated in Clinics, while case series, reviews and diagnostic studies predominated in RAMB.