This study considers the shape effect of Al2O3 nanoparticles (platelets, blades,cylindrical and bricks) dispersed in an ethylene glycol-water base fluid (50-50%) on heat transfer and fluid flow. We have considered two different entry conditions: a constant Reynolds number (Re = 250) and a constant inlet velocity (Win=0.2 m/s).The physical model was developed using Gambit CFD for mesh and FLUENT for fluid flow modeling. The three-dimensional continuity, Navier–Stokes and energy equations are solved by using the finite volume method. We found that for Re = 250, the nanofluids with nanoparticles of platelet shape have the highest velocity, heat transfer coefficient, Nusselt number, pressure drop, and performance factor followed by nanofluids containing cylindrical nanoparticles.For a constant velocity at the inlet, nanofluids with nanoparticles of cylindrical shape have the highest heat transfer coefficient and the lowest Nusselt number while nanofluids with nanoparticles of platelet shape have the lowest heat transfer coefficient and the highest Nusselt number.