Revisión actualizada del tratamiento tópico de la psoriasis

Carrascosa, J.M.; Vanaclocha, F.; Borrego, Leopoldo; Fernández‐López, Emilia; Fuertes, Ada Ferrer; Rodriguez‐Fernandez‐Freire, Lourdes; Zulaica, Á.; Tuneu, Anna; Caballé, G.; Colomé, E.; Bordas, X.; Hernanz, J.M.; Brufau, C.; Herrera, Enrique

doi:10.1016/s0001-7310(09)70534-4

Cited by 26 publications

(8 citation statements)

References 53 publications

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“…Moreover, a recent population-based study reported increased risks for schizophrenia spectrum disorders among children and adolescents who received glucocorticoid treatment (76). Of particular relevance to our findings, corticosteroids are among the most common types of treatment for psoriasis and pemphigoid 77, 78, 79 and some forms of autoimmune anemia (80). However, corticosteroids are also commonly used in the treatment of rheumatoid arthritis (81), which was negatively associated with psychosis.…”

Section: Discussionsupporting

confidence: 58%

Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis

Cullen

Holmes

Pollak

et al. 2019

Biological Psychiatry

117

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Section: Discussionsupporting

confidence: 58%

Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis

Cullen

Holmes

Pollak

et al. 2019

Biological Psychiatry

117

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“…The pharmacological target site is the D-vitamin receptor expressed by keratinocytes present in the lower epidermis, where calcipotriol inhibits proliferation and normalizes differentiation of keratinocytes during psoriasis (Knudsen et al, 2012). In a systematic quantitative review of 37 randomized controlled trials including a total of 6038 patients with moderate plaque psoriasis, the efficacy of calcipotriol is found to be comparable to that of potent corticosteroids after 8 weeks of treatment and better than that of calcitriol, tacalcitol, coal tar, and dithranol (Carrascosa et al, 2009). A major challenge for dermal drug delivery of calcipotriol is its hydrophobic nature and low penetration through impermeable stratum corneum.…”

Section: Introductionmentioning

confidence: 99%

Calcipotriol delivery into the skin as emulgel for effective permeation

Varma

Maheshwari

Navya

et al. 2014

Saudi Pharmaceutical Journal

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The objective of this work is to formulate and evaluate an emulgel containing calcipotriol for treatment of psoriasis. Emulgels have emerged as a promising drug delivery system for the delivery of hydrophobic drugs. Isopropyl alcohol and polyethylene glycol have been employed as permeation enhancers. Formulation chart is made with seven formulations, evaluated for physical parameters, drug content, viscosity, thixotropy, spreadability, extrudability, mucoadhesion, diffusion studies, skin irritation test along with short term stability studies. Carbopolis is reported to have a direct influence on appearance and viscosity of final formulation. The photomicroscopic evaluations showed the presence of spherical globules in size range of 10-15 μm. Rheograms revealed that all the formulations exhibited pseudoplastic flow. Optimized formulation (F6) had shown 86.42 ± 2.0% drug release at the end of 8 h study. The release rate through dialysis membrane and rat skin is higher when compared to commercial calcipotriol ointment. Hence it is concluded that calcipotriol can be delivered topically with enhanced penetration properties when formulated as emulgel.

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“…The applications of corticosteroids, especially to large areas, when the skin is injured, or under occlusive dressings may led to their absorption and systemic side-effects [ 1 ]. The local corticosteroids efficiency depends, at the first place, on their pharmacological potency and ability to be absorbed into the target epidermis and dermis cells [ 2 , 3 , 4 ]. Topical steroids can be divided into different groups due to their potencies.…”

Section: Introductionmentioning

confidence: 99%

A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters

et al. 2012

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The permeation properties of twenty newly synthesized α-alkoxyalkanoyl and α-aryloxyalkanoyl C-21 esters of standard corticosteroids: Fluocinolone acetonide, dexamethasone, triamcinolone acetonide and hydrocortisone were established using a PAMPA assay (70% silicone oil and 30% isopropyl myristate). The data were compared with parent corticosteroids with addition of mometasone furoate and hydrocortisone acetate. All newly synthesized corticosteroid C-21 esters have effective permeability coefficients higher then -6, mostly followed with high values of retention factors and low permeation. The examined compounds were grouped through relationship between obtained retention factors and permeation parameters (groups I–III). The classification confirmed group I (membrane retentions as well as permeation lower then 30%) for all corticosteroid standards except mometasone furoate, a potent topical corticosteroid which, with high membrane retention (81%) and low permeation (7.7%) fits into group III. The largest number of new synthesized corticosteroids C-21 esters, among them all fluocinolone acetonide C-21 esters, have high membrane retentions (32.4%–86.5%) and low permeations (1.3%–27.1%), fitting in group III. The classification was related to previously obtained anti-inflammatory activity data for the fluocinolone acetonide C-21 esters series. According to the PAMPA results the new synthesized esters could be considered as potential new prodrugs with useful benefit/risk ratio.

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Revisión actualizada del tratamiento tópico de la psoriasis

Cited by 26 publications

References 53 publications

Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis

Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis

Calcipotriol delivery into the skin as emulgel for effective permeation

A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters

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