Revision and Compilation of Health Management Plan of Khair (Acacia catechu)

Bhattarai, Rajeev; Sharma, P. C.; Wagle, Bishnu Hari; Adhikari, Angel; Acharya, Shashi Rashmi

doi:10.33002/nr2581.6853.03012

Cited by 4 publications

(4 citation statements)

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“…04 below. The yield obtained from maceration by other researchers was significantly lower, with percentages of 12.3% [6,24] and 27.3% [13,19] when rotated to enhance the yield. In contrast, our study achieved a relatively higher percentage yield of 42.96%.…”

Section: Wetting Timementioning

confidence: 73%

“…The measured variables were collected and inputted into Microsoft Excel 365 to obtain raw data. To compare the groups, the Graph Pad Instat version 5.1 software was utilized, employing one-way analysis of variance (ANOVA) followed by DoE experimental design software [13] . The results were presented as mean ± standard deviation, with Pvalues ≤0.05 indicating statistical significance.…”

Section: Discussionmentioning

confidence: 99%

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Design of Experiments (DoE) manipulation in the formulation and optimization of a traditional Ayurvedic medicine derived from dried extract of Senegalia catechu enhanced through statistical analysis

Pandey,

Pal,

Bharath

et al. 2023

J Pharmacogn Phytochem

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Introduction:In India, the regulatory body for catechu is the Food Safety and Standards Authority of India (FSSAI). The FSSAI is responsible for regulating the manufacture, sale, and distribution of food in India, including catechu. The FSSAI has set standards for the purity and quality of catechu, and it also monitors the market for adulterated catechu. The FDA (The Food and Drug Administration) is responsible for regulating the safety and efficacy of drugs and dietary supplements in the United States (US). The FDA has not approved catechu as a drug or dietary supplement, but it does regulate catechu as a food additive. The FDA has set limits on the amount of catechu that can be added to food Objective: The primary objective of this research was to involvement of design of experiments (DoE) manipulation in the formulation and optimization of a traditional Ayurvedic medicine derived from dried extract of Senegalia catechu enhanced through statistical analysis. Methodology: The dried extract of Senegalia catechu was collected and identified at the botanical herbarium garden. Subsequently, it underwent a drying process and was ground into a powder. This powder was then subjected to extraction using the digestion method, utilizing water as the solvent at a temperature of 70 °C. The resulting extract underwent phytochemical screening. Following this, the extract was utilized in the pharmaceutical development process. The optimization of the formulation for the dried extract of Senegalia catechu began with the establishment of the Quality Target Product Profile (QTPPs) for the final product. The desired outcome was an oral dispersible tablet (ODTs) that would enhance patient compliance and ensure rapid disintegration. These QTPPs served as the foundation for identifying the Critical Quality Attributes (CQAs), which included hardness, disintegration time, and mass uniformity. These attributes were utilized in all subsequent experiments. The experimental phase was divided into two main manufacturing processes is first one is direct compression and another one is wet granulation techniques. Each process was thoroughly investigated to optimize the drug product. To assess the potential risks and their impact on product quality, a comprehensive risk assessment was conducted. For the direct compression technique, a 3 2 full factorial Design (FFD) of DoE was employed to analyze the influence of the super disintegrant (26%) and lubricant range (ranging from 0.32% to 6%) on the characteristics of powder flow. On the other hand, the wet granulation technique utilized a 3 2 FFD, DoE to investigate the effects of the superdisintegrant (Ranging from 1.5% to 4.8%) and binder (ranging from 4% to 9%) on both flow properties and tablet properties. Results: The successful optimization of an Enhanced Traditional Medicine (ETM) was achieved through the design and evaluation of formulations in this study. The utilization of DoE proved to be an exceptional approach in optimizing ETM formulations, offering a range of tools that enhance compr...

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Section: Wetting Timementioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Design of Experiments (DoE) manipulation in the formulation and optimization of a traditional Ayurvedic medicine derived from dried extract of Senegalia catechu enhanced through statistical analysis

Pandey,

Pal,

Bharath

et al. 2023

J Pharmacogn Phytochem

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“…Aside from that, heartwood extract has been used in various therapeutic applications. Alkaloids provide strong anti-microbial and hypoglycemic properties (Bhattarai et al, 2020). Traditional and folk remedies are the only ones that utilize this tree for therapeutic purposes, providing more investigation into novel medicinal compounds with known activities.…”

Section: Introductionmentioning

confidence: 99%

Densitometric HPTLC analysis of the Acacia catechu wild fractions for phenolics

Pawar,

Balasubramaniam

2023

IJERR

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Traditional "Ayurvedic" medicine from India has traditionally used Acacia catechu. The herbal extract is the primary component, although there have been no attempts to standardize it as an active agent or marker. A chromatographic fingerprint represents the chemical components of herbal remedies that are therapeutically advantageous. This study suggests utilizing an HPTLC approach to assess phenols like protocatechuic acid and gallic acid in Acacia catechu extract fractions made of water, ethyl acetate, and butanol. According to the study, protocatechuic acid (11.85%) in the water fraction of the Acacia catechu is more concentrated than gallic acid (6.92%). In contrast, the ethyl acetate fraction contains more gallic acid (11%) and less protocatechuic acid (4.10%). However, the butanol fraction only has 6.62% gallic acid. By the Folin-Coicalteu method, total phenolic content was determined, and antioxidant activity of all fractions was resolute using the DPPH method. It was discovered that ethyl acetate fraction had higher phenolic content (211 mg/g) than aqueous fraction (129 mg/g) and butanol fraction (101.2 mg/g). Ethyl acetate fraction has more potent antioxidant activity than water and Butanol fractions. The research emphasizes the potential of this methodology for efficient and economical phenolic profiling, which may aid in the assessment and use of A. catechu in the nutraceutical and pharmaceutical sectors.

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“…Acacia catechu (L.f.) Willd is a deciduous and gregarious tree with a light feathery crown native to Nepal, India, and Myanmar and one of the most promising medicinal plants of the family Fabaceae [1]. A. catechu has received attention as a potential source of bioactive secondary metabolites to be used for the formulation of pharmaceutical products [2,3].…”

Section: Introductionmentioning

confidence: 99%

LC-HRMS Profiling and Antidiabetic, Antioxidant, and Antibacterial Activities of Acacia catechu (L.f.) Willd

Aryal

Adhikari

Aryal

et al. 2021

BioMed Research International

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Acacia catechu (L.f.) Willd is a profoundly used traditional medicinal plant in Asia. Previous studies conducted in this plant are more confined to extract level. Even though bioassay-based studies indicated the true therapeutic potential of this plant, compound annotation was not performed extensively. This research is aimed at assessing the bioactivity of different solvent extracts of the plant followed by annotation of its phytoconstituents. Liquid chromatography equipped with high resolution mass spectrometry (LC-HRMS) is deployed for the identification of secondary metabolites in various crude extracts. On activity level, its ethanolic extract showed the highest inhibition towards α-amylase and α-glucosidase with an IC50 of 67.8 ± 1 μg/mL and 10.3 ± 0.1 μg/mL respectively, inspected through the substrate-based method. On the other hand, the plant extract showed an antioxidant activity of 23.76 ± 1.57 μg/mL, measured through radical scavenging activity. Similarly, ethyl acetate and aqueous extracts of A. catechu showed significant inhibition against Staphylococcus aureus with a zone of inhibition (ZoI) of 13 and 14 mm, respectively. With the LC-HRMS-based dereplication strategy, we have identified 28 secondary metabolites belonging to flavonoid and phenolic categories. Identification of these metabolites from A. catechu and its biological implication also support the community-based usage of this plant and its medicinal value.

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Revision and Compilation of Health Management Plan of Khair (Acacia catechu)

Cited by 4 publications

References 0 publications

Design of Experiments (DoE) manipulation in the formulation and optimization of a traditional Ayurvedic medicine derived from dried extract of Senegalia catechu enhanced through statistical analysis

Design of Experiments (DoE) manipulation in the formulation and optimization of a traditional Ayurvedic medicine derived from dried extract of Senegalia catechu enhanced through statistical analysis

Densitometric HPTLC analysis of the Acacia catechu wild fractions for phenolics

LC-HRMS Profiling and Antidiabetic, Antioxidant, and Antibacterial Activities of Acacia catechu (L.f.) Willd

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