Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices

Bajema, Ingeborg M.; Wilhelmus, Suzanne; Alpers, Charles E.; Bruijn, Jan A.; Colvin, Robert B.; Cook, H. Terence; D’Agati, Vivette D.; Ferrario, Franco; Haas, Mark; Jennette, J. Charles; Joh, Kensuke; Nast, Cynthia C.; Noël, Laure Hélène; Rijnink, Emilie C.; Roberts, Ian S.; Seshan, Surya V.; Sethi, Sanjeev; Fogo, Agnes B.

doi:10.1016/j.kint.2017.11.023

Cited by 678 publications

(612 citation statements)

References 14 publications

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“…Nephritis [6] An overview of the updates to the ISN/RPS lesion definitions, classification and the modified National Institutes of Health (NIH) activity, and chronicity indices are shown in online supplementary Tables 1 and 2 (for all online suppl. material, see www.karger.com/ doi/10.1159/000507213).…”

Section: The 2018 Revision Of the Isn/rps Classification For Lupusmentioning

confidence: 99%

“…The 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathologic classification [4] of lupus nephritis was well accepted although limitations were noted [5]. A revision of this system has been published in 2018 [6]. This revision was derived from a meeting of an international nephropathology working group, designed to reach a consensus on issues concerning problems with definitions of lupus nephritis lesions [7].…”

Section: Introductionmentioning

confidence: 99%

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A Validation of the 2018 Revision of International Society of Nephrology/Renal Pathology Society Classification for Lupus Nephritis: A Cohort Study from China

Tao

Wang

et al. 2020

Am J Nephrol

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Background: A revision of the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification for lupus nephritis has been published in 2018. The current study aimed to verify the utility of this system. Materials and Methods: A total of 101 lupus nephritis patients from a large Chinese cohort who underwent renal biopsy in Peking University First Hospital were reevaluated by 2 renal pathologists, who had no knowledge of the clinical findings. The association between clinical data at the time of initial renal biopsy and follow-up and pathological features were further analyzed on all patients selected. Results: The mean age of the cohort was 33 years with a male/female ratio of 1: 9, and a median follow-up period of 128 months. The presence and extent of mesangial hypercellularity, endocapillary hyper-

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Section: The 2018 Revision Of the Isn/rps Classification For Lupusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Validation of the 2018 Revision of International Society of Nephrology/Renal Pathology Society Classification for Lupus Nephritis: A Cohort Study from China

Tao

Wang

et al. 2020

Am J Nephrol

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“…These tasks rely on the expertise of pathologists and much effort has been made to better define and create consensus about relevant lesions. In fact, after successive discussion and validation studies in the field, increased consistency has been achieved in the diagnosis and classification of glomerular renal diseases such as lupus nephritis, IgA nephropathy, and rejection of kidney transplant (Bajema et al, 2018;Trimarchi et al, 2017;Joosten et al, 2005). Some limiting factors to the performance of histological diagnosis are the complexity of lesions, which, in some cases, may impair a clear definition in terms of criteria and consequently a suitable agreement among pathologists (Barisoni et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Classification of glomerular hypercellularity using convolutional features and support vector machine

Chagas

Souza

Araújo

et al. 2020

Artificial Intelligence in Medicine

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Glomeruli are histological structures of the kidney cortex formed by interwoven blood capillaries, and are responsible for blood filtration. Glomerular lesions impair kidney filtration capability, leading to protein loss and metabolic waste retention. An example of lesion is the glomerular hypercellularity, which is characterized by an increase in the number of cell nuclei in different areas of the glomeruli. Glomerular hypercellularity is a frequent lesion present in different kidney diseases. Automatic detection of glomerular hypercellularity would accelerate the screening of scanned histological slides for the lesion, enhancing clinical diagnosis. Having this in mind, we propose a new approach for classification of hypercellularity in human kidney images. Our proposed method introduces a novel architecture of a convolutional neural network (CNN) along with a support vector machine, achieving near perfect average results with the FIOCRUZ data set in a binary classification (lesion or normal). Our deepbased classifier outperformed the state-of-the-art results on the same data set.Additionally, classification of hypercellularity sub-lesions was also performed, considering mesangial, endocapilar and both lesions; in this multi-classification task, our proposed method just failed in 4% of the cases. To the best of our * First two authors contributed equally.knowledge, this is the first study on deep learning over a data set of glomerular hypercellularity images of human kidney.

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“…In addition, lesions in tubulointerstitial area are connected with glomerular lesions, however, they have also been detected to be prognostic of kidney outcome in lupus nephritis irrespective of glomerular lesions. Thus, interstitial inflammation, atrophy of the tubules and fibrosis must report in the pathology reports of lupus nephritis and graded as mild, moderate, or severe (4,5). Recently much interest has been paid towards other parameters having prognostic implication for disease progression or patients' survival.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have shown that CD147 has participated in the control of metastatic cancers and lymphocyte responsiveness. In normal conditions, high expression of CD147 is detected only in the basolateral side of tubular epithelial cells (TECs) in the kidney (5,6). The role of CD147 in the kidneys are different, extending from its role in acute renal failure which is usually associated with inflammation and ischemia.…”

Section: Introductionmentioning

confidence: 99%

Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis

Amiri¹,

Abedini²,

Baradaran³

2018

J Nephropathol

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Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory disorder that affects the kidney in around 50% of patients Objectives: The aim of this study was to assess CD147 expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV lupus nephritis. Patients and Methods: These patients with lupus nephritis classes II and IV by renal biopsy and pathology were enrolled in this study. The strength of CD147 staining on tubules, Bowman's capsules, vessels and tuft of glomeruli was expressed as proportion of involvement. Results: In this study, 23 renal biopsies for lupus nephritis of classes III and IV (documented by immunofluorescence and light microscopic studies) were included. No significant difference of CD147 staining between classes was detected (P > 0.05). In addition, proportion of proteinuria was not related to CD147 staining in tubules, Bowman's capsules, vessels and tuft of glomeruli in classes III and IV lupus nephritis (P > 0.05). There was no significant association of CD147 staining in tubules, Bowman's capsules and vessels with serum creatinine (P > 0.05). However, an association between CD147 staining in tuft of glomeruli with serum creatinine was detected (r=0.623, P = 0.002). None of chronicity or activity percent of glomerular involvement in two classes of III or IV had a significant association with CD147 staining (P > 0.05). Conclusions: The significant association between CD147 staining in glomeruli with serum creatinine in lupus nephritis of classes III and IV revealed that inflammation at this area may have prognostic implication.

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Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices

Cited by 678 publications

References 14 publications

A Validation of the 2018 Revision of International Society of Nephrology/Renal Pathology Society Classification for Lupus Nephritis: A Cohort Study from China

A Validation of the 2018 Revision of International Society of Nephrology/Renal Pathology Society Classification for Lupus Nephritis: A Cohort Study from China

Classification of glomerular hypercellularity using convolutional features and support vector machine

Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis

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