Revisión sistemática de la literatura sobre el tratamiento con colchicina en pacientes adultos con osteoartritis de rodilla

Restrepo-Escobar, Mauricio; Carmona-Franceschi, Manuel de Jesús; Gómez, Jorge Hernando Donado

doi:10.1016/j.rcreu.2017.01.002

Cited by 3 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one study of patients with knee osteoarthritis, treatment with colchicine (in addition to the standard therapy) resulted in greater improvement in patientand physician-assessed outcomes at 3 months after treatment initiation [12]. A systematic review on colchicine in knee osteoarthritis stated that colchicine appears to be an effective and safe alternative for treating knee osteoarthritis, as evidenced by lower pain and improved functionality [13]. Similarly, some other studies have claimed that colchicine improves symptoms in treating knee osteoarthritis [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Colchicine is an effective therapeutic agent in erosive hand osteoarthritis

Ertürk,

Sarı

2023

J Surg Med

View full text Add to dashboard Cite

Background/Aim: The efficacy of colchicine has been assessed in hand osteoarthritis; however, no studies have investigated its use in the more severe subtype of hand osteoarthritis, known as erosive hand osteoarthritis (EHOA). This retrospective cohort study investigated whether colchicine therapy could provide symptomatic relief and improve inflammation markers in patients with EHOA. Methods: The study included a total of 43 EHOA patients using colchicine (2×0.5 mg) + paracetamol (3×500 mg) daily (colchicine group) and 43 EHOA patients using only paracetamol (3×500 mg) (standard therapy group). Both groups were evaluated for various parameters. Results: The groups were similar in terms of age, sex distribution, and other sociodemographic variables. The decreases in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels from baseline were significantly greater in the colchicine group (P<0.001). Additionally, the visual analog scale (VAS) and Australian Canadian Osteoarthritis Hand Index (AUSCAN) scores, which include pain, stiffness, function, and total score, were significantly better in the colchicine group at 3 months compared to the standard therapy group (P<0.001). Furthermore, although both groups showed significant improvements in these parameters, the amount of improvement was significantly greater in the colchicine group (P<0.001). Conclusion: The combined use of colchicine and paracetamol improved CRP and ESR levels, VAS score, and all AUSCAN scores in patients with EHOA. Moreover, these benefits were significantly greater than standard therapy with paracetamol alone. Colchicine appears to be an effective therapeutic agent in the treatment of EHOA.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Studies on the use of colchicine in knee osteoarthritis have presented inconsistent results [12][13][14][15]. On the other hand, to the best of our knowledge, only two studies have been conducted so far on the use of colchicine in HOA, which did not report positive results [2,16].…”

Section: Introductionmentioning

confidence: 99%

Colchicine is an effective therapeutic agent in erosive hand osteoarthritis

Ertürk,

Sarı

2023

J Surg Med

View full text Add to dashboard Cite

show abstract

“…A systematic review and meta-analysis revealed the positive effects of colchicine in pain reduction and physical functioning of adult patients with knee OA. 5 Nonetheless, the quality of this evidence is limited since the review only included five randomized control trials with small sample size and considerable risk of bias. Given that this systematic review of the literature was conducted in November 2016, an update on this topic is justified to improve the quality of the evidence about the efficacy and safety of colchicine on any type of OA.…”

Section: Background and Rationalementioning

confidence: 99%

Efficacy and safety of colchicine for the treatment of osteoarthritis: protocol for a systematic review and meta-analysis of intervention trials

Molina-García

Singh

Hussain

et al. 2020

Preprint

View full text Add to dashboard Cite

Colchicine, in the form of Colchicum autumnale, has been used to treat joint swelling for centuries. The anti-inflammatory action o colchicine and the higher prevalence of calcium pyrophosphate crystal deposition (CPPD) in osteoarthritis (OA) joints have led to th use of colchicine as a potential treatment for OA, however, the quality of the evidence on this regards is still limited. The curren protocol aims to conduct a systematic review and meta-analysis proving the efficacy and safety of colchicine for the treatment of adul patients with OA. For that purpose, Scopus®, Web of Sciences®, Medline® and Cochrane Library® will be inspected for the availabl trials testing the efficacy and safety of colchicine for the treatment of any type of OA (e.g., hand, knee or hip). Cochrane tool will b used to assess the risk of bias of included trials. A meta-analysis of dichotomous (e.g., adverse events) or continuous data (e.g., mea difference in pain scale) will be performed depending on the data reporting. Review Manager 5 (RevMan) and RStudio Version 1.2.133 will be used to conduct the statistical analysis.

show abstract