Revisit percutaneous dissolution of uric acid stones: A case report with review

Abstract

Two main risk factors for uric acid stones formation are low urinary pH and hyperuricosuria. Of these two major risk factors, acidic (low, <5.5) urinary pH is most common and it is usually caused by tubular disorders, low urinary volume, chronic diarrhea, or severe dehydration. Hyperuricuria (>800mg of urinary uric acid/24hrs) can be associated with hyperuricemia, such as in primary gout or myeloproliferative disorder, or may manifest as an isolated cause due to diet or uricosuric drugs. 7 The monogenic metabolic conditions such as Lesch-Nyhan also predisposes to uric acid nephrolithiasis. A gene ZNF365 located on chromosome 10q21-q22 linked to uric acid calculus formation is detected but its purpose is not well defined yet. 8 Recent analysis from multiple retrospective studies by Daudon et al. 9 has concluded that within frequent stones formers, uric acids stones are most common in patients who have diabetes, obesity, or metabolic syndrome. 9