Revisiting and refining roles of neural guidance cues in circuit assembly

Dorskind, Joelle M.; Kolodkin, Alex L.

doi:10.1016/j.conb.2020.07.005

Cited by 29 publications

(31 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Udvary et al, 2021). Mechanisms establishing the characteristic intracortical axonal guidance and branching of different cell types remain incompletely understood but likely include extrinsic molecular cues such as semaphorin, Wnt, netrin, and ephrin family members, interactions with radial glia, selective stabilization of axon collaterals and the cellular migration patterns of inhibitory neurons (Fame et al, 2011;Leyva-Diaz and Lopez-Bendito, 2013;Hand et al, 2015;Dorskind and Kolodkin, 2021). For example, both SST Martinotti cells and translaminar PV interneurons migrate through the marginal zone before arriving into position in the cortex, and preventing this migration impairs the growth of their axonal arbors into the appropriate target layers (Lim et al, 2018b).…”

Section: Cell-type-specific Neurite Morphologies Constrain Possible Synaptic Partnersmentioning

confidence: 99%

“…During development, the intracortical axons and dendrites of cortical cell types reach their appropriate laminar destinations (Larsen and Callaway, 2006;Fame et al, 2011;Gibson and Ma, 2011;Kalil and Dent, 2014;Hand et al, 2015;Dorskind and Kolodkin, 2021), and there encounter multiple classes of synaptic targets. They must then select the correct cell types and postsynaptic domains within those cell types with which to form synaptic connections (Thomson and Lamy, 2007;Brown and Hestrin, 2009a;Krook-Magnuson et al, 2012;Harris and Shepherd, 2015;Kubota et al, 2016;Tremblay et al, 2016;Chevée and Brown, 2018;Kast and Levitt, 2019;Anastasiades and Carter, 2021).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Gutman-Wei

Brown

2021

Front. Neural Circuits

View full text Add to dashboard Cite

The cerebral cortex contains numerous neuronal cell types, distinguished by their molecular identity as well as their electrophysiological and morphological properties. Cortical function is reliant on stereotyped patterns of synaptic connectivity and synaptic function among these neuron types, but how these patterns are established during development remains poorly understood. Selective targeting not only of different cell types but also of distinct postsynaptic neuronal domains occurs in many brain circuits and is directed by multiple mechanisms. These mechanisms include the regulation of axonal and dendritic guidance and fine-scale morphogenesis of pre- and postsynaptic processes, lineage relationships, activity dependent mechanisms and intercellular molecular determinants such as transmembrane and secreted molecules, many of which have also been implicated in neurodevelopmental disorders. However, many studies of synaptic targeting have focused on circuits in which neuronal processes target different lamina, such that cell-type-biased connectivity may be confounded with mechanisms of laminar specificity. In the cerebral cortex, each cortical layer contains cell bodies and processes from intermingled neuronal cell types, an arrangement that presents a challenge for the development of target-selective synapse formation. Here, we address progress and future directions in the study of cell-type-biased synaptic targeting in the cerebral cortex. We highlight challenges to identifying developmental mechanisms generating stereotyped patterns of intracortical connectivity, recent developments in uncovering the determinants of synaptic target selection during cortical synapse formation, and current gaps in the understanding of cortical synapse specificity.

show abstract

Section: Cell-type-specific Neurite Morphologies Constrain Possible Synaptic Partnersmentioning

confidence: 99%

mentioning

confidence: 99%

Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Gutman-Wei

Brown

2021

Front. Neural Circuits

View full text Add to dashboard Cite

show abstract

“…It is conceivable that other membrane proteins can drive the formation of phaseseparated clusters and future research will have to determine how widespread this mechanism is. For example, it is interesting to speculate that this may be involved in axon guidance since extracellular cues are known to induce local changes in the actin cytoskeleton, thereby influencing growth cone steering (Dorskind and Kolodkin, 2020).…”

Section: Biomolecular Condensates Can Influence the Cytoskeletonmentioning

confidence: 99%

Complex Interactions Between Membrane-Bound Organelles, Biomolecular Condensates and the Cytoskeleton

Koppers

Özkan

Farı́as

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Membrane-bound and membraneless organelles/biomolecular condensates ensure compartmentalization into functionally distinct units enabling proper organization of cellular processes. Membrane-bound organelles form dynamic contacts with each other to enable the exchange of molecules and to regulate organelle division and positioning in coordination with the cytoskeleton. Crosstalk between the cytoskeleton and dynamic membrane-bound organelles has more recently also been found to regulate cytoskeletal organization. Interestingly, recent work has revealed that, in addition, the cytoskeleton and membrane-bound organelles interact with cytoplasmic biomolecular condensates. The extent and relevance of these complex interactions are just beginning to emerge but may be important for cytoskeletal organization and organelle transport and remodeling. In this review, we highlight these emerging functions and emphasize the complex interplay of the cytoskeleton with these organelles. The crosstalk between membrane-bound organelles, biomolecular condensates and the cytoskeleton in highly polarized cells such as neurons could play essential roles in neuronal development, function and maintenance.

show abstract

“…The complexity of specifying synaptic connectivity in the developing central nervous system (CNS) is daunting. A large body of work has identified several mechanistic principles that address specificity but also flexibility for neural wiring (Dorskind and Kolodkin, 2021;Favuzzi et al, 2019;Hassan and Hiesinger, 2015;Linneweber et al, 2020;Riccomagno and Kolodkin, 2015;Sanes and Zipursky, 2020;Wang and Clandinin, 2016;Yogev and Shen, 2014). In particular, cell-surface receptors and adhesion molecules have been recognized as key mediators of neurite targeting (de Wit and Ghosh, 2016;Sperry, 1963).…”

Section: Introductionmentioning

confidence: 99%

The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing

Landínez-Macías

Bratus-Neuenschwander

et al. 2021

Cell Reports

View full text Add to dashboard Cite

show abstract

Revisiting and refining roles of neural guidance cues in circuit assembly

Cited by 29 publications

References 74 publications

Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Complex Interactions Between Membrane-Bound Organelles, Biomolecular Condensates and the Cytoskeleton

The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing

Contact Info

Product

Resources

About