Revisiting carboxylic group functionalization of silica sol–gel materials

Rivas, María Verónica; Muñetón, María José Arenas; Spagnuolo, Carla; Lombardo, M. Verónica; Bordoni, Andrea; Wolosiuk, Alejandro

doi:10.1039/d2tb02279f

Cited by 6 publications

(2 citation statements)

References 193 publications

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“…Meanwhile, they can be easily linked or conjugated to the surface of UCNPs to facilitate functionalization. To facilitate linkage or surface conjugation, the surface of UCNPs is typically subject to further modifications, such as stripping ligand [ 98 ] and altering ligand molecules by introducing functional groups like carboxyl, [ 149 ] amino, [ 150 ] aldehyde, [ 151 ] thiol, [ 152 ] and more. Amino acids can serve dual roles as stabilizers and functionalizers of UCNPs.…”

Section: Ucnps Biosensorsmentioning

confidence: 99%

Upconversion Nanoparticles Based Sensing: From Design to Point‐of‐Care Testing

Wu,

Wei

et al. 2024

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Rare earth‐doped upconversion nanoparticles (UCNPs) have achieved a wide range of applications in the sensing field due to their unique anti‐Stokes luminescence property, minimized background interference, excellent biocompatibility, and stable physicochemical properties. However, UCNPs‐based sensing platforms still face several challenges, including inherent limitations from UCNPs such as low quantum yields and narrow absorption cross–sections, as well as constraints related to energy transfer efficiencies in sensing systems. Therefore, the construction of high‐performance UCNPs‐based sensing platforms is an important cornerstone for conducting relevant research. This work begins by providing a brief overview of the upconversion luminescence mechanism in UCNPs. Subsequently, it offers a comprehensive summary of the sensors’ types, design principles, and optimized design strategies for UCNPs sensing platforms. More cost‐effective and promising point‐of‐care testing applications implemented based on UCNPs sensing systems are also summarized. Finally, this work addresses the future challenges and prospects for UCNPs‐based sensing platforms.

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Section: Ucnps Biosensorsmentioning

confidence: 99%

Upconversion Nanoparticles Based Sensing: From Design to Point‐of‐Care Testing

Wu,

Wei

et al. 2024

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“…Recent studies by Singh N. and Tkalec G. [ 8 , 18 ] have indicated that silica aerogels could be viable for drug delivery systems [ 19 , 20 ]. Researchers investigated the silica aerogels impregnated with the number of active pharmaceutical ingredients (API) by conducting adsorption experiments.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

Khodov

Sobornova

Mulloyarova

et al. 2023

IJMS

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This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure 13C NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO2 sorption. Additionally, a high-pressure T1–T2 relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel’s pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released from the aerogel. The results indicate that mefenamic acid is affected by the chemical environment of the aerogel, altering the ratio of mefenamic acid conformers from 75% to 25% in its absence to 22% to 78% in the presence of aerogel.

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