Revisiting Chordoma With Brachyury, a “New Age” Marker: Analysis of a Validation Study on 51 Cases

Jambhekar, Nirmala A.; Rekhi, Bharat; Thorat, Kiran; Dikshit, Rajesh; Agrawal, Manindra; Puri, Ajay

doi:10.5858/2009-0476-oa.1

Cited by 94 publications

(14 citation statements)

References 16 publications

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“…Microscopic evaluation of hibernomas demonstrate large, multi-vacuolated adipocytes with a “foamy” appearance and paracentrically placed nuclei [46] . Immunohistochemically, hibernoma cells are known to characteristically stain positive for S-100, while staining negative for cytokeratin and brachyury [47] . Given the wide differential based on radiographic assessment alone, including lipoma, atypical lipomatous tumor, liposarcoma, angiolipoma, notochordal rest, and clear cell sarcoma [48] , this immunohistochemical pattern is essential for accurately diagnosing an intraosseous hibernoma.…”

Section: Discussionmentioning

confidence: 99%

Intraosseous hibernoma: Two case reports and a review of the literature

Weiss

Mohla

Zhu

et al. 2022

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Intraosseous hibernoma: Two case reports and a review of the literature

Weiss

Mohla

Zhu

et al. 2022

Radiology Case Reports

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“…According to Shen et al [ 15 ], those brachyury negative parts might be bound up with the fetal notochordal cells, as they reported that brachyury staining was negative in the BNCT component around chordomas and was negative in fetal notochordal cell rests, which are histopathologically similar to BNCTs. Jambhekar et al [ 16 ] have reported the expression rate of brachyury in chordomas was 90.2%, therefore, some other sensitive but less specific markers, including CK (AE1/AE3), EMA, S100, were usually recommended to be used in combination [ 9 ]. In our case, the brachyury-positive pattern was consistent with most of the literatures aforementioned, and CK (AE1/AE3), EMA, S100 were positively stained, strongly suggested notochordal differentiation.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tumor with Notochordal differentiation: a case report and morphologic, Immunohistochemical and molecular study of benign Notochordal cell tumor originating in the lung

Song

et al. 2021

Diagn Pathol

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Background Extraosseous benign notochordal cell tumor is extremely rare, and there are only five reported cases worldwide. The presented case of pulmonary primary benign notochordal cell tumor is the sixth case, but the first to report the deletion mutation of EGFR gene exon 19. Case presentation The patient was a 50-year-old asymptomatic woman, who had been followed up for 3 years for a nodule in the right lung. After ten months of the wedge resection, the patient is alive without evidence of recurrence or metastasis. The tumor was 7 mm in diameter and was well demarcated. The tumor was consisted of a sheet of large round vacuolated cells with small and bland nuclei. No connective tissue containing blood vessels or inflammatory cell infiltration was detected in the stroma. The tumor was positive for CK AE1/AE3, Vimentin, S100 and Brachyury. EGFR gene mutation and amplification were not detected. Conclusions We firstly reported the positive immunohistochemical staining for EGFR and the negative molecular results of EGFR gene of pulmonary primary benign notochordal cell tumor. Due to the rarity of this tumor, more reports are needed to explore pathological characteristics, especially the molecular characteristics, in order to better understand the nature of tumors.

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“…Other tumors don't show expression of this protein; hence it can be used as a diagnostic marker for chordomas [30]. It was also found that some differentiated zones of chordomas may show a loss of brachyury immune-reactivity [31]. Synaptophysin and Desmin can be used for staining purposes which is less Challenges in Diagnosing Chordoma (Skull Base Tumors) DOI: http://dx.doi.org/10.5772/intechopen.102048 pathologically explored.…”

Section: Photomicrographs From a Case Of Chordoma A) Tumor Cells With...mentioning

confidence: 99%

Challenges in Diagnosing Chordoma (Skull Base Tumors)

Chowhan¹,

Kale²

2022

Skull Base Surgery

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Chordoma is a rare bone malignancy that influences the spine and cranium base. Once in a while, it includes bone and when it does, cranial bones are the favored location. Chordomas emerge from embryonic remnants of the primitive notochord and chondrosarcomas from primitive mesenchymal cells, otherwise from the embryonic rest of the cranial cartilaginous matrix. Chondrosarcomas constitute a heterogeneous group of essential bone malignancy characterized by hyaline cartilaginous neoplastic tissue. Both are characterized by invasion and pulverization of the neighboring bone and delicate tissue with higher locoregional reappearance frequency. Chordoma and chondrosarcoma, especially myxoid variation of chondrosarcoma of the cranium base, are as often as possible amalgamated because of similar anatomic location, clinical presentation, and radiologic sightings, and mixed up histopathological highlights. Chordoma and chondrosarcoma vary with respect to their origin, management strategy, and contrast particularly with respect to outcome. Ultimately, developing indication supports aberrant growth factor signaling as possible pathogenic mechanisms in chordoma. Here, we have shown such a location-based symptomatic predicament, understood effectively with ancillary immunohistochemistry. In this review, we summarize the most recent research findings and focus primarily on the pathophysiology and diagnostic aspects.

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Revisiting Chordoma With Brachyury, a “New Age” Marker: Analysis of a Validation Study on 51 Cases

Cited by 94 publications

References 16 publications

Intraosseous hibernoma: Two case reports and a review of the literature

Intraosseous hibernoma: Two case reports and a review of the literature

Pulmonary tumor with Notochordal differentiation: a case report and morphologic, Immunohistochemical and molecular study of benign Notochordal cell tumor originating in the lung

Challenges in Diagnosing Chordoma (Skull Base Tumors)

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