Revisiting evidence of primary prevention of suicide among adult populations: A systematic overview

Altavini, Camila Siebert; Asciutti, Antonio Paulo Rinaldi; Solis, Ana Cristina de Oliveira; Wang, Yuan‐Pang

doi:10.1016/j.jad.2021.10.076

Cited by 6 publications

(3 citation statements)

References 74 publications

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“…Treatment of specific suicidal risk in patients with bipolar disorder must therefore also incorporate broader interventions based on the individual’s specific risk factors 165. Such an approach would include societal interventions like means restriction166 and a number of empirically tested suicide focused psychotherapy treatments 167168. Unfortunately, the availability of appropriate training, expertise, and care models for such treatments remains limited, even in higher income countries 169…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and management of bipolar disorders

Goes

2023

BMJ

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Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect around 2% of the world’s population and encompass a spectrum between severe elevated and excitable mood states (mania) to the dysphoria, low energy, and despondency of depressive episodes. The illness commonly starts in young adults and is a leading cause of disability and premature mortality. The clinical manifestations of bipolar disorder can be markedly varied between and within individuals across their lifespan. Early diagnosis is challenging and misdiagnoses are frequent, potentially resulting in missed early intervention and increasing the risk of iatrogenic harm. Over 15 approved treatments exist for the various phases of bipolar disorder, but outcomes are often suboptimal owing to insufficient efficacy, side effects, or lack of availability. Lithium, the first approved treatment for bipolar disorder, continues to be the most effective drug overall, although full remission is only seen in a subset of patients. Newer atypical antipsychotics are increasingly being found to be effective in the treatment of bipolar depression; however, their long term tolerability and safety are uncertain. For many with bipolar disorder, combination therapy and adjunctive psychotherapy might be necessary to treat symptoms across different phases of illness. Several classes of medications exist for treating bipolar disorder but predicting which medication is likely to be most effective or tolerable is not yet possible. As pathophysiological insights into the causes of bipolar disorders are revealed, a new era of targeted treatments aimed at causal mechanisms, be they pharmacological or psychosocial, will hopefully be developed. For the time being, however, clinical judgment, shared decision making, and empirical follow-up remain essential elements of clinical care. This review provides an overview of the clinical features, diagnostic subtypes, and major treatment modalities available to treat people with bipolar disorder, highlighting recent advances and ongoing therapeutic challenges.

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Section: Treatmentmentioning

confidence: 99%

Diagnosis and management of bipolar disorders

Goes

2023

BMJ

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“…Gordon L. Flett 1 , Paul L. Hewitt 2 For several decades, research-based efforts have sought broadly applicable suicide prevention methods. A recent umbrella review of meta-analyses or systematic reviews of primary prevention found some limited evidence for multicomponent programs tailored for specific populations, and the possible value of restricting access to lethal means such as guns or pesticides, but concluded that there is "insufficient evidence to recommend a widespread implementation of suicide primary prevention in the general population" 1 .…”

mentioning

confidence: 99%

Can a practical process‐oriented strategy prevent suicidal ideation and behavior?

Hayes,

Pistorello

2024

World Psychiatry

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“…4 Recent reviews indicate that multicomponent frameworks have positive effects when replicable interventions are built according to the characteristics of the target population. 5 Hence, a cogent suicide prevention program should be designed for each age cohort.…”

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confidence: 99%