Lagrangian models are powerful tools to study atmospheric transport processes. However, conducting large-scaleLagrangian transport simulations with many air parcels can become numerically rather costly. In this study, we assessed the potential of exploiting graphics processing units (GPUs) to accelerate Lagrangian transport simulations. We ported the Massive-Parallel Trajectory Calculations (MPTRAC) model to GPUs using the open accelerator (OpenACC) programming model. The trajectory calculations conducted within the MPTRAC model have been fully ported to GPUs, i. e., except for feeding in the meteorological input data and for extracting the particle output data, the code operates entirely on the GPU devices without frequent data transfers between CPU and GPU memory. Model verification, performance analyses, and scaling tests of the MPI/OpenMP/OpenACC hybrid parallelization of MPTRAC have been conducted on the JUWELS Booster supercomputer operated by the Jülich Supercomputing Centre, Germany. The JUWELS Booster comprises 3744 NVIDIA A100 Tensor CoreGPUs, providing a peak performance of 71.0 PFlop/s. As of June 2021, it is the most powerful supercomputer in Europe and listed among the most energy-efficient systems internationally. For large-scale simulations comprising 100 million particles driven by the European Centre for Medium-Range Weather Forecasts’ ERA5 reanalysis, the performance evaluation showed a maximum speedup of a factor of 16 due to the utilization of GPUs compared to CPU-only runs on the JUWELS Booster. In the large-scale GPU run, about 67 % of the runtime is spent on the physics calculations, being conducted on the GPUs. Another 15 % of the runtime is required for file-I/O, mostly to read the ERA5 data from disk. Meteorological data preprocessing on the CPUs also requires about 15 % of the runtime. Although this study identified potential for further improvements of the GPU code, we consider the MPTRAC model to be ready for production runs on the JUWELS Booster in its present form. The GPU code provides a much faster time to solution than the CPU code, which is particularly relevant for near-real-time applications of a Lagrangian transport model