Revisiting Solitary Pedunculated Lipofibromas

Adotama, Prince; Hutson, Seneca D; Rieder, Evan A.; Stein, Jennifer A.; Kim, Randie H.

doi:10.1093/ajcp/aqab075

Cited by 4 publications

(16 citation statements)

References 18 publications

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“…4 The solitary type, or pedunculated lipofibroma, presents as a dome-shaped, slow-growing, pedunculated mass usually after thirty years of age. 6 This form can occur on buttocks, thighs and non-pelvic areas, such as axillae, arms, knees, ears, and scalp and is termed as fibrolipoma, 6,7 similar to our cases.…”

Section: Discussionsupporting

confidence: 71%

Doppelganger solitary pedunculated tumours in pelvic girdle of obese females: Histopathological study of three cases.

Gaffoor¹,

Shetty²,

Murali³

et al. 2022

JCBS

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Pedunculated tumours are soft, compressible skin-coloured solitary lesions, predominantly occurring on buttocks and thighs that need to be categorized rightly. We describe three solitary pedunculated masses of the pelvic girdle encountered in obese females. Primary clinical differential diagnoses included fibroepithelial polyps, lipoma, papilloma and nevus lipomatosus superficialis. Histopathological features helped in narrowing down definitive diagnosis of these look alike lesions as pedunculated lipofibroma or solitary form of Nevus Lipomatosus Cutaneous Superficialis (NCLS) which is a broad-based lesion with aggregates of mature adipocytes extending into the dermis and Fibroepithelial polyp which displays loose dermal fibrocollagenous stroma with entrapped blood vessels in the absence of admixed adipose tissue. Though treatment of choice for these lesions is excision, it would be of interest for pathologists to be acquainted with these clinical mimics displaying divergent histology. Keywords: Adipocytes, Nevus, Pelvis, Polyps

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Section: Discussionsupporting

confidence: 71%

Doppelganger solitary pedunculated tumours in pelvic girdle of obese females: Histopathological study of three cases.

Gaffoor¹,

Shetty²,

Murali³

et al. 2022

JCBS

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“…Clinically recognizable clustered segmentally distributed pelvic girdle papules, polyps, and coalescing plaques that are histopathologically composed of nodules of mature adipose tissue within the dermis constitute the classic multiple forms in children and young adults. [1][2][3][4][5][6][7][8][9][10][11][12] Single fibroepithelial polyps occurring in other body sites that contain intradermal adipose tissue are considered by some authors as a solitary variant of nevus lipomatosus in older adults, while others consider them to represent a variant of a large fat-containing skin tag or so-called pedunculated lipofibroma. 10,11 Because both forms show identical histopathologic features despite their different clinical manifestations, most authors lump the apparently two distinct clinicopathologic entities under nevus lipomatosus.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12] Single fibroepithelial polyps occurring in other body sites that contain intradermal adipose tissue are considered by some authors as a solitary variant of nevus lipomatosus in older adults, while others consider them to represent a variant of a large fat-containing skin tag or so-called pedunculated lipofibroma. 10,11 Because both forms show identical histopathologic features despite their different clinical manifestations, most authors lump the apparently two distinct clinicopathologic entities under nevus lipomatosus. [1][2][3][4][5][6][7][8]11,12 There are different postulations regarding the origin of nevus lipomatosus.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8]11,12 There are different postulations regarding the origin of nevus lipomatosus. [1][2][3][4][5][6][7][8][9][10][11][12] Some authors have proposed that stromal degeneration of the dermal collagenous and elastic tissue results in metaplastic adipocytic changes. Permeation from the underlying subcutaneous adipose tissue and mesenchyme along the perivascular spaces into the dermis has been suggested.…”

Section: Discussionmentioning

confidence: 99%

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Nevus lipomatosus superficialis: A series of six cases

AbdullGaffar,

Keloth

2023

J Cutan Pathol

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Nevus lipomatosus still imposes diagnostic, categorization, and etiologic challenges. Even though an intradermal adipose tissue is a histopathologic prerequisite, the lesions are clinically divided into classic multiple forms and a solitary variant, which some consider a separate so‐called lipofibroma clinicopathologic entity. This further complicates the true prevalence, classification and etiopathogenesis of nevus lipomatosus. Case reports and series studies have reflected either consistent or variable and sometimes conflicting clinicopathologic findings. A few have reported electron microscopic findings. Immunohistochemistry is lacking. We report two multiple and four solitary forms of nevus lipomatosus in six patients, highlighting their salient histopathologic features and immunohistochemical profile. Both forms showed intradermal groups of perivascular S100+ lipogenic and CD34+ mesenchymal cells intermixed with scattered CD1a+ and FXIIIa+ dendrocytes, CD3 lymphocytic and CD117 mast cells in a fibromyxoid milieu. Epidermal nevoid and comedonal follicular alterations, attenuated dermal connective tissue and adnexal structures were variably present in both forms. We compared our findings with seven series of studies reporting classic and solitary forms. Both forms showed similar histopathologic findings, comparable clinicopathologic features, predominantly pelvic, and shoulder girdle distribution patterns in bimodal age onsets. Even though some lipomatous skin lesions clinically and histopathologically overlap with nevus lipomatosus, certain findings are helpful distinguishing features. Small intradermal islands of lipocytic fibroplasia have characteristic perivascular milieu that may function as a niche of preadipose CD34 mesenchymal stem cells. They are most likely represented in the dermis of the pelvic and shoulder areas in certain individuals prone to maintain these embryonic reservoirs, which are clinically manifested at different ages. Some may have unifocal or multifocal residues reflecting multiple and solitary forms.

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“…The differential diagnosis of the classical type includes mucinous nevus [12], sebaceous nevus, hemangioma, hairy nevus, lymphangioma, and focal dermal hyperplasia (Goltz syndrome). The solitary type is often confused with skin tags, solitary neurofibromas, and solitary lipofibromas [13].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The Nevus Lipomatosus Superficialis of Face: A Case Report and Literature Review

Yang,

Park

2023

Arch Plast Surg

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Nevus lipomatosus superficialis (NLS) is a hamartoma of adipose tissue, rarely reported in the past 100 years. We treated one case, and we conducted a systematic review of the literature. A 41-year-old man presented with a cutaneous multinodular lesion in the posterior region near the right auricle. The lesion was excised and examined histopathologically. To review the literature, we searched PubMed with the keyword “NLS.” The search was limited to articles written in English and whose full text was available. We analyzed the following data: year of report, nation of corresponding author, sex of patient, age at onset, duration of disease, location of lesion, type of lesion, associated symptoms, pathological findings, and treatment. Of 158 relevant articles in PubMed, 112 fulfilled our inclusion criteria; these referred to a total of 149 cases (cases with insufficient clinical information were excluded). In rare cases, the diagnosis of NLS was confirmed when the lesion coexisted with sebaceous trichofolliculoma and Demodex infestation. Clinical awareness of NLS has increased recently. NLS is an indolent and asymptomatic benign neoplasm that may exhibit malignant behavior in terms of huge lesion size and specific anatomical location. Early detection and curative treatment should be promoted.

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Revisiting Solitary Pedunculated Lipofibromas

Cited by 4 publications

References 18 publications

Doppelganger solitary pedunculated tumours in pelvic girdle of obese females: Histopathological study of three cases.

Doppelganger solitary pedunculated tumours in pelvic girdle of obese females: Histopathological study of three cases.

Nevus lipomatosus superficialis: A series of six cases

The Nevus Lipomatosus Superficialis of Face: A Case Report and Literature Review

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