2023
DOI: 10.3390/molecules28196962
|View full text |Cite
|
Sign up to set email alerts
|

Revisiting Supersaturation of a Biopharmaceutical Classification System IIB Drug: Evaluation via a Multi-Cup Dissolution Approach and Molecular Dynamic Simulation

Yanxiong Gan,
Yaxin Xu,
Xue Zhang
et al.

Abstract: As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the gastrointestinal tract, leading to less qualified in vitro–in vivo correlation (IVIVC). This study aims to develop a physiologically based multi-cup dissolution approach to improve the evaluation of the supersaturation for a higher quality of IVIVC and preliminarily explores the molecular mechanism of supersaturation and precipitation of … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
8
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 38 publications
(8 citation statements)
references
References 38 publications
0
8
0
Order By: Relevance
“…Frontier molecular orbital (FMO) predicts the most reactive location in the π-electron system, as well as numerous conjugated-system reactions. [42,43] The HOMO depicts significant donor orbitals, whereas the LUMO depicts prominent acceptor orbitals. The positive phase is symbolized by blue colour, whereas the negative phase is shown by red colour.…”
Section: Dft Simulationmentioning
confidence: 99%
“…Frontier molecular orbital (FMO) predicts the most reactive location in the π-electron system, as well as numerous conjugated-system reactions. [42,43] The HOMO depicts significant donor orbitals, whereas the LUMO depicts prominent acceptor orbitals. The positive phase is symbolized by blue colour, whereas the negative phase is shown by red colour.…”
Section: Dft Simulationmentioning
confidence: 99%
“…ERRAT is based on the fundamental principle that proteins contain different types of atoms, and these atoms tend to arrange themselves in a nonrandom fashion relative to one another . The α-glucosidase model demonstrated a remarkable overall quality factor of 91.115%.…”
Section: Resultsmentioning
confidence: 99%
“…[167,168] This field is swiftly progressing, exploiting the distinctive physical and chemical attributes of nanoparticles to enable precise, rapid, sensitive, and cost-effective diagnostic techniques. [169][170][171][172] NDs possess a nitrogen-vacancy configuration that induces fluorescence upon illumination, [173][174][175] and their magnetic properties can serve as MRI contrast agents. [174] Although limited, studies have explored the utility of NDs in infectious disease diagnosis.…”
Section: Nds In Diagnosis Of Infectionmentioning
confidence: 99%