Revisiting the acute kidney injury in Wistar rats experimentally envenomated with Bothrops jararacussu venom

Romanelli, Mayara A.; Soeiro, Paula A.; Silva, Raquel Costa da; Taveira-da-Silva, Rosilane; Melo, Paulo A.; Lara, Lucienne S.

doi:10.1016/j.toxicon.2021.06.004

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“…In a recent study, acute kidney injury was not able to be replicated in rats with sub-lethal doses of D. russelii venom suggesting it to be a poor model for venom-induced acute kidney injury (Wijewickrama et al, 2018). VICC, AKI and thrombocytopaenia only occurred with experimental venom doses that were unrealistically higher than what is observed in actual human envenomings, making it difficult to match the reallife envenoming scenarios in humans (Tan et al, 2012;Romanelli et al, 2021;Thomazini et al, 2021;Yamamoto et al, 2021).…”

Section: Introductionmentioning

confidence: 99%