Revisiting the conversion of muscle into meat and the underlying mechanisms

Ouali, Ahmed; Herrera-Mendez, Carlos H.; Coulis, Gérald; Becila, Samira; Boudjellal, Abdelghani; Aubry, Laurent; Sentandreu, Miguel Ángel

doi:10.1016/j.meatsci.2006.05.010

Cited by 327 publications

(306 citation statements)

References 118 publications

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“…MDA is the end product of lipid peroxidation induced by excessive ROS, which reflected the degree of lipid peroxidation, and also was one of the indices of cellular injury. Our results showed that 500 mg/kg CHI could elevate the level of T-SOD, and decreased MDA content of serum to enhance anti-oxidative function in beef cattle, which was beneficial particularly for fattener, because the meat quality was related to antioxidative capacity of organism (Ouali et al 2006). In addition, it is worth mentioning that the oxidative injury in animals caused by stress (e.g.…”

Section: Discussionmentioning

confidence: 69%

Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle

Li¹,

Na²,

Yu³

et al. 2015

CZECH J ANIM SCI

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The present experiment was conducted to study the effects of chitosan (CHI) on immune and antioxidative function in beef cattle. A total of 24 fattening Simmental cattle with similar body weight and age were divided randomly into three dietary groups, and the three diets contained 0, 500, and 1000 mg/kg CHI, respectively. The feeding trial lasted for 84 days. It was found that: (1) the addition of CHI in diets improved (P < 0.05) the levels of IgA and interleukin-1, and decreased (P < 0.1) the levels of soluble cluster of differentiation 4 receptor in serum at middle stage except that IgA remained unchanged in 1000 mg/kg CHI group. The levels of IgM and IgA tended to be increased (P < 0.1) by dietary CHI at later stage of the experiment; (2) the addition of 500 mg/kg CHI in diets increased (P < 0.1) total superoxide dismutase activity and decreased (P < 0.05) malondialdehyde content in serum at early and later stages, respectively. In conclusion, these results indicated that addition of 500 mg/kg CHI affected humoral and cellular immune responses, and improved the antioxidative function of beef cattle.

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Section: Discussionmentioning

confidence: 69%

Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle

Li¹,

Na²,

Yu³

et al. 2015

CZECH J ANIM SCI

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“…This could account for muscle hypertrophy in both DM foetuses and DM cows. However, attenuated apoptosis is not likely to contribute to meat tenderness as to the hypothesis of Ouali et al (2006) in conventional meat-producing animals, especially as caspases have been identified as potential contributors to post-mortem tenderization. Indeed, tenderness of DM cattle would rather be linked to the collagen content of their muscles (Ashmore et al, 1974;Uytterhaegen et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Myostatin inactivation induces a similar muscle molecular signature in double-muscled cattle as in mice

Chelh

Picard

Hocquette

et al. 2011

Animal

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Myostatin (MSTN), a member of the TGF-b superfamily, is a negative regulator of skeletal muscle mass. We have previously shown that the cell survival/apoptosis pathway is a downstream target of MSTN loss-of-function in mice through the regulation of the expression or abundance of many survival and apoptotic factors. In this study, we used western-blot and quantitative PCR (qPCR) analyses to validate these novel downstream targets of MSTN in double-muscled (DM) cattle v. their controls including 260-day-old foetuses and adult cows from the INRA95 strain. MSTN loss-of-function in DM foetuses and DM cows resulted in a glycolytic shift of the muscles (e.g. upregulation of H-MyBP, PGM1 and SNTA1 and downregulation of H-FABP), activation of cell survival pathway through regulation of some components of the PI3K/Akt pathway (e.g. upregulation of DJ-1 and Gsk-3bser9/ Gsk-3btotal ratio and downregulation of PTEN) and upregulation of cell survival factors translationally controlled tumour protein (14-3-3E, Pink1). We also found a lower abundance of pro-apoptotic transcripts and/or proteins (Caspase-3, caspase-8, caspase-9, BID, ID2 and Daxx) and a higher expression of anti-apoptotic transcripts (Traf2 and Bcl2l2) in DM muscles. All together, these results are in favour of activation of the cell survival pathway and loss of apoptosis pathway within the muscles of DM animals. Alteration of both pathways may increase myonuclear or satellite cell survival, which is crucial for protein synthesis. This could contribute to muscle hypertrophy in DM foetuses and DM cows.Keywords: myostatin, cattle, muscle hypertrophy, apoptosis, cell survival ImplicationsMuscle hypertrophy has been extensively studied in meatproducing animals. In double-muscled (DM) cattle, a loss-offunction mutation in the myostatin gene (MSTN ) is responsible for muscle hypertrophy. In order to get a thorough knowledge of the molecular mechanisms of MSTN action, we have examined the molecular phenotype of DM muscle based on our previous data in MSTN-null mice. The data bring new elements to the understanding of the DM muscle phenotype and of the regulation of muscle mass in farm animals.

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“…First of all, we want to consider the trend of two proteins belonging to the family of heat shock proteins (HSPs), HSPB6 and αB-crystallin. The importance of HSP into the muscle-to-meat conversion has been recently recognized and associated to meat tenderization [2] and [53], although there is no clear hypothesis about the biological mechanisms underpinning postmortem events. Furthermore, a link between HSP and apoptosis [54], [55] and [56] is ascertained, evidence that endorses the attention on HSP identifications in our time course experiment.…”

Section: Omic Clues Towards Apoptosismentioning

confidence: 99%