Revisiting the Cutaneous Impact of Oral Hormone Replacement Therapy

Pierard, Gérald; Humbert, Philippe; Berardesca, Enzo; Gaspard, Ulysse; Hermanns‐Lê, Trinh; Piérard-Franchimont, C

doi:10.1155/2013/971760

Cited by 32 publications

(20 citation statements)

References 46 publications

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“…Reduced estrogen levels during menopause affect skin components with estrogen receptors, particularly in epidermal cells and sebaceous glands. 60 By contrast, androgenic hormone levels do not decline significantly during this period. Although the response to this new ratio of sexual hormones is often clinically mistaken for the natural functional decline of the skin, menopause can increase xerosis, changes in texture and capillary density, and dermal atrophy.…”

Section: Systemic Morbidities and Drugsmentioning

confidence: 79%

Beyond photoaging: additional factors involved in the process of skin aging

Addor¹

2018

CCID

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Studies assessing the impact of extrinsic factors on skin aging have increased during the last with the increase in life expectancy. Although most of the studies are about the sun radiation impact, many factors should be considered in elderly people, beyond environmental conditions. Lifestyle factors, like diet, sleeping, smoking, should be analyzed carefully, as common age-related conditions (menopause, diabetes, pulmonary diseases, etc.). All these factors could accelerate the natural decline of skin structure and functions, possibly affecting the responses to treatments and drugs. This review demonstrates that growing evidence regarding environmental factors that are associated with lifestyle and comorbidities deserve greater attention from researchers and dermatologists and may require new approaches in the management of skin aging.

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Section: Systemic Morbidities and Drugsmentioning

confidence: 79%

Beyond photoaging: additional factors involved in the process of skin aging

Addor¹

2018

CCID

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“…postmenopausal women. Indeed, HRT controls in part the dermal thickness and laxity, and the collagen content and density, as well as the tissue mechanical reactivity to stress [237]. Physicians and patients have become extremely reluctant concerning HRT following the WHI study.…”

Section: H Hormone Replacement Therapymentioning

confidence: 99%

Skin Aging & Modern Age Anti-aging Strategies

Mohiuddin¹

2019

GJMR

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

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“…The deleterious effect of ultraviolet light on specific skin structures is beyond doubt 4. In addition, endocrine factors are clearly involved in the dermal thinning that occurs during estrogen reduction in the climacteric period 5–11. Hence, hormonal aging with impaired tissue trophicity is likely superimposed on the effects of chronic sun exposure during the global process of facial skin aging.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric facial skin viscoelasticity during climacteric aging

Pierard¹,

Hermanns‐Lê²,

Gaspard³

et al. 2014

CCID

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BackgroundClimacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the aging process.MethodsSkin viscoelasticity was compared on both cheeks in premenopausal and post-menopausal women with indoor occupational activities somewhat limiting the influence of chronic sun exposure. Eighty-four healthy women comprising 36 premenopausal women and 48 early post-menopausal women off hormone replacement therapy were enrolled in two groups. The tensile characteristics of both cheeks were tested and compared in each group. A computerized suction device equipped with a 2 mm diameter hollow probe was used to derive viscoelasticity parameters during a five-cycle procedure of 2 seconds each. Skin unfolding, intrinsic distensibility, biological elasticity, and creep extension were measured.ResultsBoth biological elasticity and creep extension were asymmetric on the cheeks of the post-menopausal women. In contrast, these differences were more discrete in the premenopausal women.ConclusionFacial skin viscoelasticity appeared to be asymmetric following menopause. The possibility of asymmetry should be taken into account in future studies of the effects of hormone replacement therapy and any antiaging procedure on the face in menopausal women.

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Revisiting the Cutaneous Impact of Oral Hormone Replacement Therapy

Cited by 32 publications

References 46 publications

Beyond photoaging: additional factors involved in the process of skin aging

Beyond photoaging: additional factors involved in the process of skin aging

Skin Aging & Modern Age Anti-aging Strategies

Asymmetric facial skin viscoelasticity during climacteric aging

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