Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques

Yen, Shaoyu; Wu, Hongyi; Wang, Yuhling; Huang, Chih‐Mao; Wu, Changwei; Chen, Jyh-Horng; Liao, Lun-De

doi:10.1016/j.isci.2023.106354

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…Additionally, aerobic exercise not only increases the BDNF concentrations but also elevates the levels of glial fibrillary acidic protein and neuronal nuclei in the brain. This evidence suggested the potential of aerobic exercise to enhance the brain's functionality in the vascular system, thus resulting in an overall improvement in cognitive function 10 . As a result, driven by the benefits of aerobic exercise on the brain, studies within the fields of neuroscience and cognitive psychology have actively delved into investigating the impact of aerobic exercise on the aging brain with the utilization of non-invasive neuroimaging techniques 11 , 12 .…”

Section: Introductionmentioning

confidence: 95%

Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging

Wu,

Huang,

Hsu

et al. 2024

Sci Rep

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Preservation of executive function, like inhibition, closely links to the quality of life in senior adults. Although neuroimaging literature has shown enhanced inhibitory function followed by aerobic exercise, current evidence implies inconsistent neuroplasticity patterns along different time durations of exercise. Hence, we conducted a 12-week exercise intervention on 12 young and 14 senior volunteers and repeatedly measured the inhibitory functionality of distinct aspects (facilitation and interference effects) using the numerical Stroop task and functional Magnetic Resonance Imaging. Results showcased improved accuracy and reduced reaction times (RT) after 12-week exercise, attributed to frontoparietal and default mode network effects. In young adults, the first phase (0 to six weeks) exercise increased the activation of the right superior medial frontal gyrus, associated with reduced RT in interference, but in the second intervention phase (six to twelve weeks), the decreased activation of the left superior medial frontal gyrus positively correlated with reduced RT in facilitation. In senior adults, the first six-week intervention led to reduced activations of the inferior frontal gyrus, inferior parietal gyrus, and default mode network regions, associated with the reduced RT in interference. Still, in the second intervention phase, only the visual area exhibited increased activity, associated with reduced RT in interference. Except for the distinctive brain plasticity between the two phases of exercise intervention, the between-group comparison also presented that the old group gained more cognitive benefits within the first six weeks of exercise intervention; however, the cognitive improvements in the young group occurred after six weeks of intervention. Limited by the sample size, these preliminary findings corroborated the benefits of aerobic exercise on the inhibitory functions, implying an age × exercise interaction on the brain plasticity for both facilitation and interference.

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Section: Introductionmentioning

confidence: 95%

Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging

Wu,

Huang,

Hsu

et al. 2024

Sci Rep

Self Cite

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“…One may envision CSD as a brain-driven self-rescue system to reallocate available resources to neurons across the brain. In fact, a study on rats concluded that CSD can also be induced by exercise and the CSD leads to beneficial effects in cerebrovascular system functions and increased cerebrovascular stability ( 123 ).…”

Section: The Cause Of Migrainementioning

confidence: 99%

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Stanton

2024

Front. Nutr.

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This article presents a hypothesis explaining the cause of migraines, suggesting that electrolyte imbalance, specifically a lack of sufficient sodium in the extracellular space of sensory neurons, leads to failed action potentials. The author argues that migraines are triggered when sodium channels fail to initiate action potentials, preventing communication between neurons. The article discusses the evolutionary perspective of the migraine brain, stating that migraineurs have a hypersensitive brain with more sensory neuronal connections, making them more reactive to environmental stimuli and in need of more minerals for the increased sensory neuronal communication. Since glucose is often used to reduce serum hypernatremia, it follows that a high carbohydrate diet reduces sodium availability for use in the brain, causing an electrolyte imbalance. Low carbohydrate diets, such as ketogenic, low carb-high fat (LCHF), and carnivore (all animal products), can be beneficial for migraineurs by reducing/eliminating carbohydrate intake, thereby increasing sodium availability. In support, many research papers and some anecdotal evidences are referred to. The article concludes by proposing lifestyle modifications, such as dietary changes and sodium intake management. These will provide migraineurs with a long-term healthy metabolic foundation helping them to maintain strong nutritional adherence and with that aiding continued proper neuronal functioning and migraine free life.

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“…Our laboratory can simultaneously perform ECoG LSCI (hereinafter referred to as ECoG-LSCI) to record and comprehensively evaluate neurovascular function. 26 …”

Section: Introductionmentioning

confidence: 99%

Investigating cerebral neurovascular responses to hyperglycemia in a rat model of type 2 diabetes using multimodal assessment techniques

Yen,

Wang,

Liao

2024

iScience

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Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques

Cited by 5 publications

References 71 publications

Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging

Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Investigating cerebral neurovascular responses to hyperglycemia in a rat model of type 2 diabetes using multimodal assessment techniques

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