Revisiting the hallmarks of cancer: The role of hyaluronan

Caon, Ilaria; Bartolini, Barbara; Parnigoni, Arianna; Caravà, Elena; Moretto, Paola; Viola, Manuela; Karousou, Evgenia; Vigetti, Davide; Passi, Alberto

doi:10.1016/j.semcancer.2019.07.007

Cited by 147 publications

(133 citation statements)

References 143 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…[156][157][158][159] The striking effect of HA on tumor progression is highly associated with its molecular weight and interactions with other proteins in the ECM. 160,161 Low molecular weight (LMW) HA has well-established tumorigenic proprieties. 161,162 In breast cancer, decreasing LMW-HA production significantly inhibits cancer cell migration and invasion.…”

Section: Epithelial-mesenchymal Transition: What Is New?mentioning

confidence: 99%

Molecular principles of metastasis: a hallmark of cancer revisited

Fares

Khachfe

et al. 2020

Sig Transduct Target Ther

1,538

935

View full text Add to dashboard Cite

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process. The invading tumor cell, on its way to the target site, interacts with other proteins and cells. Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges, settle, and colonize. These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. In this review, the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.

show abstract

Section: Epithelial-mesenchymal Transition: What Is New?mentioning

confidence: 99%

Molecular principles of metastasis: a hallmark of cancer revisited

Fares

Khachfe

et al. 2020

Sig Transduct Target Ther

1,538

935

View full text Add to dashboard Cite

show abstract

“…Hyaluronan is an extracellular matrix component that absorbs water in tissues. Due to its hydrating nature, hyaluronan has many commercial uses, including cosmetic applications, but it also regulates the proliferation of certain stem cell populations and may enable certain hallmarks of cancer [1,2]. Hyaluronan receptors, such as Cluster of differentiation 44 (CD44), are highly expressed on stem cells in normal tissues and tumor-initiating cells isolated from neoplastic tissues [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Mei

Connell

et al. 2020

Cells

View full text Add to dashboard Cite

Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement. Consequently, CD44 demarks stem cells in normal tissues and tumor-initiating cells isolated from neoplastic tissues. Hyaluronan mediated motility receptor (HMMR, also known as RHAMM) is another one of few defined hyaluronan receptors. HMMR is also associated with neoplastic processes and its role in cancer progression is often attributed to hyaluronan-mediated signaling. But, HMMR is an intracellular, microtubule-associated, spindle assembly factor that localizes protein complexes to augment the activities of mitotic kinases, like polo-like kinase 1 and Aurora kinase A, and control dynein and kinesin motor activities. Expression of HMMR is elevated in cells prior to and during mitosis and tissues with detectable HMMR expression tend to be highly proliferative, including neoplastic tissues. Moreover, HMMR is a breast cancer susceptibility gene product. Here, we briefly review the associations between HMMR and tumorigenesis as well as the structure and evolution of HMMR, which identifies Hmmr-like gene products in several insect species that do not produce hyaluronan. This review supports the designation of HMMR as a homeostasis, mitosis, and meiosis regulator, and clarifies how its dysfunction may promote the tumorigenic process and cancer progression.

show abstract

“…In healthy tissues, ECM is a dynamic microenvironment submitted to remodeling and degradation [30]. Deposited proteins include collagens, fibronectin [31], proteoglycans [32,33], elastic fibres, and many others. They are mainly degraded by various enzymes including the matrix metalloproteinases (MMPs) [30].…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

Roy

Magne

Vaillancourt-Audet

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitrohuman 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.

show abstract

Revisiting the hallmarks of cancer: The role of hyaluronan

Cited by 147 publications

References 143 publications

Molecular principles of metastasis: a hallmark of cancer revisited

Molecular principles of metastasis: a hallmark of cancer revisited

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

Contact Info

Product

Resources

About