Revisiting the management of recurrent implantation failure through freeze-all policy

Magdi, Yasmin; El-Damen, Ahmed; Fathi, Ahmed Mohamed; Abdelaziz, Ahmed Mostafa; Youssef, Mohamed; Abdallah, Ahmed; Elawady, Mona Ahmed; Ahmed, Mohammed Ahmed Ibrahim; Edris, Yehia

doi:10.1016/j.fertnstert.2017.04.020

Cited by 46 publications

(26 citation statements)

References 37 publications

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“…The freeze‐all policy may also be indicated for those patients with previous implantation failure, although it is critical that implantation failure is defined precisely. Shapiro et al .…”

Section: Discussionmentioning

confidence: 99%

“…These findings led to the implementation of the freeze-all policy, and several studies have shown improvements in IVF clinical outcome when this strategy was implemented in patients with good prognosis [2][3][4][5][6] and in those with previous implantation failure 37,38 . The most recent randomized clinical trial 6 evaluated 1508 infertile women with polycystic ovarian syndrome who underwent a first IVF cycle, comparing fresh ET to elective frozen-thawed ET.…”

Section: Discussionmentioning

confidence: 99%

“…The freeze-all policy may also be indicated for those patients with previous implantation failure 37,38 , although it is critical that implantation failure is defined precisely. Shapiro et al 37 evaluated retrospectively 269 patients with at least one previous failed fresh ET, who underwent another fresh ET or freeze-all strategy in the subsequent cycle.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Roque

Valle

Sampaio

et al. 2018

Ultrasound in Obstet & Gyne

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The freeze-all strategy, compared with fresh ET, had no impact on IVF outcomes in POR patients as defined according to the Bologna criteria. Multicenter studies including large numbers of patients should be carried out to confirm the results of this study and reach conclusions about the potential benefits of the freeze-all policy for poor responders. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Roque

Valle

Sampaio

et al. 2018

Ultrasound in Obstet & Gyne

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“…This phenomenon can be explained by a possible asynchrony between the embryo and the endometrium, a fact that was not detected in egg‐donor cycles or embryo thaw cycles (Richter, Shipley, McVearry, Tucker, & Widra, ; Shapiro, Daneshmand, Garner, Aguirre, & Ross, ). Such evidence has led to the practice of cryopreservation of all oocytes or embryos of the cohort and transfer in a subsequent cycle, free of the action of gonadotrophins, the so‐called freeze‐all policy (Chang et al, ; Roque, ; Roque, Valle, Guimaraes, Sampaio, & Geber, ), with the possibility of leading to superior results (Braga et al, ; Chang et al, ; Magdi et al, ; Roque, ; Roque et al, ; Roque, Valle, Guimaraes, Sampaio, & Geber, ; Shapiro, Daneshmand, Garner, Aguirre, & Hudson, ; Zhu et al, ). In addition, the freeze‐all policy allows the personalized embryo transfer, at the defined moment of the WOI and the stage of development of the embryo, after access to the stage of endometrial development.…”

Section: Discussionmentioning

confidence: 99%

Lipidomic profile as a noninvasive tool to predict endometrial receptivity

Braga

Borges

Godoy

et al. 2018

Molecular Reproduction Devel

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For the present study we asked whether the endometrial fluid lipidomic may be a useful approach to predict endometrial receptivity in freeze‐all cycles. For this case‐control study, endometrial fluid samples were collected from 41 patients undergoing freeze‐all cycles. Samples were split depending on the pregnancy outcome: positive group (n = 24) and negative group (n = 17). Data were acquired by the matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS‐DA) were applied. A list of potential biomarker ion ratios was obtained and the values were used to build a receiver operating characteristic (ROC) curve to predict pregnancy success. The lipid categories were attributed by LIPID MAPS database. Ion ratios were established according to their correlations and used for the analysis. The PCA showed a tendency of separation between the studied groups, whereas the PLS‐DA was able to clearly distinguish them. Fifteen ratios (13 hyper‐represented in the negative and two hyper‐represented in the positive group) were selected according to their importance for model prediction. These ratios were used to build the ROC curve, which presented an area under curve of 84.0% (95%CI: 69.2–97.4%; p = 0.009). These findings suggest that lipidomic profiling of endometrial fluid may be a valuable tool for identifying the time interval comprising the window of implantation.

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“…It is yet to be proven, but there may also be benefit to the freeze-all approach in cases of recurrent implantation failure. 24,25 A common reason for an unplanned freeze-all strategy is ovarian hyperstimulation syndrome (OHSS). If an embryo implants during a cycle complicated by or at high risk of OHSS, the resultant rise in human chorionic gonadotrophin (hCG) is associated with an increase in the inflammatory mediator vascular endothelial growth factor and a prolonged, more severe clinical course.…”

Section: Widening Indications For Embryo Freezingmentioning

confidence: 99%

The role of frozen–thawed embryo replacement cycles in assisted conception

Noble

Child

2019

The Obstetric & Gynaecologis

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Recent years have seen a dramatic rise in the number of frozenthawed embryo replacement (FER) cycles. Improved embryo cryopreservation techniques have resulted in outcomes for FER that are similar to fresh embryo transfer. FER maximises the cumulative live-birth rate of a fresh in vitro fertilisation (IVF) cycle by using excess embryos and encourages a policy of single embryo transfer; this has contributed to a fall in the multiple pregnancy rate associated with IVF. Freezing all suitable embryos in a fresh cycle reduces the risk of ovarian hyperstimulation syndrome. The endometrium is prepared for FER by a natural or medicated protocol; the optimum method is unknown. Learning objectives To appreciate the importance of FER in IVF practice. To understand the current debate surrounding fresh versus frozen IVF. To understand the indications for, and methods of, embryo cryopreservation. To understand the commonly used methods of endometrial preparation for FER. To be able to date an FER pregnancy. Ethical issues Funding from the National Health Service (NHS) for embryo storage and FER varies widely across the UK; where funding is limited, this can result in viable embryos being discarded. When an embryo is created by a couple, the consent of both partners is required before transferring the embryo.

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Revisiting the management of recurrent implantation failure through freeze-all policy

Cited by 46 publications

References 37 publications

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Does freeze‐all policy affect IVF outcome in poor ovarian responders?

Lipidomic profile as a noninvasive tool to predict endometrial receptivity

The role of frozen–thawed embryo replacement cycles in assisted conception

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