Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders

Teixeira, Antônio Lúcio; Gama, Clarissa Severino; Rocha, Natália Pessoa; Teixeira, Mauro Martins

doi:10.3389/fpsyt.2018.00241

Cited by 108 publications

(91 citation statements)

References 52 publications

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“…Th-2 cytokines [8] (Teixeira AL et al, 2018) [9] (Sirivichayakul S et al, 2018) [10] (Kindstedt E et al, 2017) Interleukin IL-4…”

Section: Cytokines and Other Molecules Inducing Ccl-11 Referencesmentioning

confidence: 99%

“…Furthermore, there is some evidence that CCL-11 is associated with aging and reduced neurogenesis [12]. Increased levels of CCL-11 have been detected in numerous neuro-inflammatory disorders such as multiple sclerosis [13], as well as neurodegenerative and neuroprogressive disorders including Alzheimer's disease [8] and psychiatric illnesses including major depression, bipolar disorder and schizophrenia [8,11,[13][14][15]. Moreover, increased CCL-11 levels are also associated with neurocognitive deficits in aging, neurodegenerative disorders and major psychiatric disorders such as schizophrenia [11].…”

Section: Complement Factorsmentioning

confidence: 99%

“…Moreover, increased CCL-11 plasma levels are also associated with increased severity scores on different symptom domains of schizophrenia [8,9,[50][51][52]. First, in schizophrenia, positive correlations were established between increased CCL-11 levels and negative symptoms [8,9,50,52], but also with psychosis, hostility, excitation, mannerism and psychomotor retardation [9,50,51]. The impact of CCL-11 on these symptoms may be increased by combining CCL-11 levels with other neurotoxic compounds including tryptophan catabolites such as picolinic and xanthurenic acid [11].…”

Section: Ccl-11 In Schizophreniamentioning

confidence: 99%

“…Chemokines consist of a family of small cytokines (7)(8)(9)(10)(11)(12), which prompt directed chemotaxis in nearby responsive cells. Chemokines play a pivotal role in immune functions and inflammatory responses and facilitate leukocyte migration and trafficking [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…One of those chemokines, namely CCL-11 or eosinophil chemotactic protein (eotaxin), is involved in the selective recruitment of eosinophils into inflammatory sites during allergic reactions, and this chemokine is extensively examined in asthma, allergic rhinitis and other eosinophil-related conditions [8].…”

Section: Introductionmentioning

confidence: 99%

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CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

et al. 2020

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Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper reviews the associations between CCL-11 and aging, neurodegenerative, neuroinflammatory and neuropsychiatric disorders. Methods: Electronic databases were searched for original articles examining CCL-11 in neuropsychiatric disorders. Results: CCL-11 is rapidly transported from the blood to the brain through the blood-brain barrier. Age-related increases in CCL-11 are associated with cognitive impairments in executive functions and episodic and semantic memory, and therefore, this chemokine has been described as an “Endogenous Cognition Deteriorating Chemokine” (ECDC) or “Accelerated Brain-Aging Chemokine” (ABAC). In schizophrenia, increased CCL-11 is not only associated with impairments in cognitive functions, but also with key symptoms including formal thought disorders. Some patients with mood disorders and premenstrual syndrome show increased plasma CCL-11 levels. In diseases of old age, CCL-11 is associated with lowered neurogenesis and neurodegenerative processes, and as a consequence, increased CCL-11 increases risk towards Alzheimer’s disease. Polymorphisms in the CCL-11 gene are associated with stroke. Increased CCL-11 also plays a role in neuroinflammatory disease including multiple sclerosis. In animal models, neutralization of CCL-11 may protect against nigrostriatal neurodegeneration. Increased production of CCL-11 may be attenuated by glucocorticoids, minocycline, resveratrol and anti-CCL11 antibodies. Conclusions: Increased CCL-11 production during inflammatory conditions may play a role in human disease including age-related cognitive decline, schizophrenia, mood disorders and neurodegenerative disorders. Increased CCL-11 production is a new drug target in the treatment and prevention of those disorders.

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“…Th-2 cytokines [8] (Teixeira AL et al, 2018) [9] (Sirivichayakul S et al, 2018) [10] (Kindstedt E et al, 2017) Interleukin IL-4…”

Section: Cytokines and Other Molecules Inducing Ccl-11 Referencesmentioning

confidence: 99%

Section: Complement Factorsmentioning

confidence: 99%

Section: Ccl-11 In Schizophreniamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

et al. 2020

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Assessing the role of eosinophil‐mediated immune response markers in detecting hookworm infection: A case‐control study in Kintampo, Ghana

Sakyi

Amoani

Opoku

et al. 2022

Health Science Reports

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Background and Aim: Human hookworm disease caused by Ancylostoma duodenale and Necator americanus is a serious public health problem. Hookworm infection activates eosinophil-mediated tissue inflammatory responses, involving the production of the eosinophil-specific chemokine (eotaxin), recruitment of eosinophils, secretion of the cationic protein, and production of antiparasite immunoglobulin E (IgE). We investigated eosinophil-mediated immune response as markers (CCL11, eosinophil cationic protein [ECP], and IgE) for detecting hookworm infection.Methods: This case-control study was carried out in hookworm endemic areas within the Kintampo North Municipality.Forty hookworm-positive subjects and 36 apparently healthy individuals were recruited as cases and controls, respectively.Stool samples were collected for hookworm detection by the Kato-Katz technique and speciation by polymerase chain reaction. Approximately, 5 ml of intravenous blood was used to obtain plasma for the immunological assays.Results: Of eosinophil-mediated immune response markers studied, ECP and CCL11 were significantly higher among hookworm patients compared to controls.Increasing CCL11 (β = −0.81, p = 0.015) was associated with a significant decrease hookworm intensity. However, increasing eosinophil count (β = 0.62, p = 0.027) was associated with significant increase in hookworm intensity. In receiver operator characteristics analysis, ECP could significantly detect hookworm infection with a very high area under the curve (AUC) (AUC = 0.97, p < 0.0001). At a cutoff of 39.05, ECP was the best eosinophil-mediated immune response marker for detecting hookworm infection with a sensitivity of 97.2%, specificity of 87.8%, a positive predictive value of 89.7%, and a negative predictive value of 96.6%. Conclusion:ECP best predicts eosinophil-mediated immune response for detecting hookworm infection, while CCL11 and eosinophil count better predict the intensity of hookworm. Moreover, the ECP level is a good indicator of hookworm infection

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HDAC4 depletion ameliorates IL‐13‐triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF‐κB signaling

Wang

Chen

et al. 2022

Immunity Inflam & Disease

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Introduction Allergic rhinitis (AR) is frequently known as a chronic respiratory disease with a global high prevalence. The pivotal roles of histone deacetylase 4 (HDAC4) in multiple human diseases have been underlined by numerous studies. Nevertheless, whether HDAC4 is implicated in AR remains to be elaborated. The objective of the current study is to clarify the impacts of HDAC4 on AR. Methods First, human nasal epithelial cells (hNECs) were pretreated by interleukin‐13 (IL‐13). HDAC4 expression in hNECs with the presence or absence of IL‐13 treatment was tested by quantitative reverse‐transcription polymerase chain reaction (RT‐qPCR) and western blot. Following, after HDAC4 was depleted, levels of histamine, Immunoglobulin E (IgE) and inflammatory factors were analyzed by ELISA assay. Then, Mucin‐5AC (MUC5AC) expression was examined through RT‐qPCR, western blot, and IF assay. Western blot was to analyze the expression of sirtuin 1 (SIRT1)/nuclear factor‐kappaB (NF‐κB) signaling‐related proteins. After IL‐13‐induced hNECs were cotransfected with HDAC4 interference plasmids and SIRT1 inhibitor EX527, the functional experiments above were conducted again. Results The experimental data in this study presented that HDAC4 expression was increased in IL‐13‐induced hNECs. Silencing of HDAC4 cut down the levels of histamine, IgE and inflammatory factors and the expression of MUC5AC. Additionally, knockdown of HDAC4 led to the activation of SIRT1/NF‐κB signaling. Further, the downregulated levels of histamine, IgE and inflammatory factors and the expression of MUC5AC imposed by HDAC4 interference were all reversed by EX527. Conclusions In short, HDAC4 inhibition activated SIRT1/NF‐κB signaling to mitigate inflammatory response and mucus production in IL‐13‐treated nasal epithelial cells in AR.

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Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders

Cited by 108 publications

References 52 publications

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

Assessing the role of eosinophil‐mediated immune response markers in detecting hookworm infection: A case‐control study in Kintampo, Ghana

HDAC4 depletion ameliorates IL‐13‐triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF‐κB signaling

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