Work-family research has blossomed over the past several decades but mostly remains focused on traditional couples and heteronormative individuals. However, research suggests that LGBTQ+ employees face unique challenges, such as discrimination and stigma, that impact their work-family interface in ways that current work-family research may not be fully capturing. We propose a review and synthesis that summarizes current LGBTQ+ and work-family literature with four primary goals: (1) identify predictors and outcomes of the work-family interface for LGBTQ+ employees, (2) integrate empirical findings and current theory into a recently developed framework to delineate our understanding of LGBTQ+ work-family experiences, (3) provide direction for future research, and (4) provide recommendations on translating the current findings into practice. Our results identify k = 74 studies that cover the work-family interface and LGBTQ+ individuals. This comprehensive and integrated review will help inform researchers on how to best address unique research questions for LGBTQ+ employees and provide employers with empirical evidence as they develop inclusive policies, cultures, and workforces.