2014
DOI: 10.1111/ene.12465
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Revisiting the spectrum of lower motor neuron diseases with snake eyes appearance on magnetic resonance imaging

Abstract: The snake eyes sign on magnetic resonance imaging is associated with a wide spectrum of neurological conditions and is more common in young men with a history of strenuous activity or antecedent trauma. The recognition of this syndrome is crucial as many of these patients are initially misdiagnosed with ALS.

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Cited by 59 publications
(33 citation statements)
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“…However, none had contrast MR study with neck flexion. Further, there were patients with proximal affection unlike our cohort and their mean age at onset ranged from 30 to 40 years (12).…”
Section: Discussionmentioning
confidence: 81%
“…However, none had contrast MR study with neck flexion. Further, there were patients with proximal affection unlike our cohort and their mean age at onset ranged from 30 to 40 years (12).…”
Section: Discussionmentioning
confidence: 81%
“…It has been reported in a number of diseases, such as complex cervical spondylosis, Hirayama disease, poliomyelitis, encephalitis caused by HIV infection, spinal cord infarction, neuromyelitis optica, paraneoplastic neurological syndrome and flail arm syndrome [20, 21]. Neuroimaging-documented appearance of the “owl’s eye” sign may reflect cystic necrosis in the central gray matter near the ventrolateral posterior column, and is consequently regarded as an unfavorable prognostic factor for the recovery of upper-extremity motor weakness, due to the destruction of gray matter accompanied by significant neuronal loss in the anterior horn [22].…”
Section: Discussionmentioning
confidence: 99%
“…Qualitative cues may be nonspecific and require careful appraisal. The specificity and sensitivity of 'owl's eyes' or 'snake's eye' signs on axial imaging is relatively poor but may indicate cord infarction, PLS or ALS in the appropriate clinical context [9]. Similarly, the 'inverted V sign' or hyperintensities of the dorsal columns is nonspecific and may be observed in subacute combined degeneration of the cord, copper deficiency myeloneuropathy and tabes dorsalis.…”
Section: Current Practice: Methods Challenges and Limitationsmentioning
confidence: 99%