We investigate the construction of four-family N = 1 supersymmetric Pati-Salam models from Type IIA T 6 /(Z 2 ×Z 2 ) orientifold with intersecting D6-branes. Utilizing the deterministic algorithm introduced in Ref.[1], we obtain 274 types of models with three rectangular tori and distinct gauge coupling relations at string scale, while 6 types of models with two rectangular tori and one titled torus. In both cases, there exists a class of models with gauge coupling unification at string scale. In particular, for the models with two rectangular tori, one tilted torus and gauge coupling unification, the gaugino condensations are allowed, and thus supersymmetry breaking and moduli stabilization are possible for further phenomenological study. Contents 1 Introduction 1 2 Basics of Ì 6 /( 2 × 2 )-Orientifolds Model Construction 3 3 Gauge Symmetry Breaking via Brane Splittings 6 3.1 T-Duality and its Variations 9 3.2 Supersymmetric 4-family Models 11 3.2.1 Models without Tilted Torus 11 3.2.2 Models with One Tilted Torus 12 4 Phenomenological Analysis 13 4.1 Models without Tilted Torus 13 4.2 Models with One Tilted Torus 17 5 Discussions and Conclusions 18 A Four-Family Standard Models from Intersecting D6-Branes without Tilted Tori 23 B Four-Family Standard Models from Intersecting D6-Branes with One Tilted Torus 31