Revisiting the synthesis of aryl nitriles: a pivotal role of CAN

Abstract

An unconventional dual behaviour of ceric ammonium nitrate was explored in the cyanation of aryl halides (I/Br). Diverse aryl nitriles were synthesized, in moderate to good yields, with the new cyanating source: CAN–DMF.

Synthesis, Characterization, and Catalytic Study of Caffeine-Derived N-heterocyclic Carbene Palladium Complexes

“…The organic phase was collected, dried over Na 2 SO 4 , concentrated, and subjected to column chromatography (SiO 2 : petroleum ether/EA v/v 50/1 to 20/1) to give the corresponding product. 1 H NMR spectra of all compounds are in full agreement with those previously reported in the literature …”

Recent advances in Chan–Lam coupling reaction

“…Bora and research team put forward an excellent strategy for the Chan-Lam coupling of amines, primary amides and 3-aminophenols using phenylboronic acid and phenyl boronic acid pinacol ester as nucleophilic coupling partners. 30 They introduced an excellent [Cu 2 (OAc) 2 (DMU) 2 ] catalytic system, which was beneficial to fabricate N-arylated anilines, mono-arylated primary amides and chemoselective N-arylated 3-aminophenols. The N-arylated anilines were obtained in moderate to good yields by reacting aryl boronic acids with anilines in the presence of 10 mol% Cu(OAc) 2 •H 2 O and 25 mol% DMU using 1 equiv.…”