Revisiting the Warburg Effect with Focus on Lactate

Kociánová, Eva; Piatrikova, Viktoria; Golias, Tereza

doi:10.3390/cancers14246028

Cited by 34 publications

(30 citation statements)

References 142 publications

(186 reference statements)

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“…Confirmation of FTC is challenging even after thyroid lobectomy, as areas where there is capsular or vascular invasion may be missed. Another of the challenges that is persistent is the inability to accurately diagnose the extent of vascular invasion, which is required for the differentiation of mi-FTC from wi-FTC [ 86 , 211 ]. That a low-risk WDTC has become high-risk or de-differentiated may also go unnoticed following FNAC, diagnostic lobectomy, or total thyroidectomy [ 10 , 54 , 55 , 57 , 86 , 98 , 162 ].…”

Section: Multi-omics Of Follicular Carcinoma and Other Thyroid Tumorsmentioning

confidence: 99%

Multi-Omics and Management of Follicular Carcinoma of the Thyroid

et al. 2023

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Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid gland, accounting for up to 20% of all primary malignant tumors in iodine-replete areas. The diagnostic work-up, staging, risk stratification, management, and follow-up strategies in patients who have FTC are modeled after those of papillary thyroid carcinoma (PTC), even though FTC is more aggressive. FTC has a greater propensity for haematogenous metastasis than PTC. Furthermore, FTC is a phenotypically and genotypically heterogeneous disease. The diagnosis and identification of markers of an aggressive FTC depend on the expertise and thoroughness of pathologists during histopathological analysis. An untreated or metastatic FTC is likely to de-differentiate and become poorly differentiated or undifferentiated and resistant to standard treatment. While thyroid lobectomy is adequate for the treatment of selected patients who have low-risk FTC, it is not advisable for patients whose tumor is larger than 4 cm in diameter or has extensive extra-thyroidal extension. Lobectomy is also not adequate for tumors that have aggressive mutations. Although the prognosis for over 80% of PTC and FTC is good, nearly 20% of the tumors behave aggressively. The introduction of radiomics, pathomics, genomics, transcriptomics, metabolomics, and liquid biopsy have led to improvements in the understanding of tumorigenesis, progression, treatment response, and prognostication of thyroid cancer. The article reviews the challenges that are encountered during the diagnostic work-up, staging, risk stratification, management, and follow-up of patients who have FTC. How the application of multi-omics can strengthen decision-making during the management of follicular carcinoma is also discussed.

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Section: Multi-omics Of Follicular Carcinoma and Other Thyroid Tumorsmentioning

confidence: 99%

Multi-Omics and Management of Follicular Carcinoma of the Thyroid

et al. 2023

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“…Tumor suppressor p53 and oncogenes (SRC, AKT, RAS) are linked to the transcription factors HIF and oncogenic MYC. All the glycolytic enzymes have isoenzymes which are targets for HIF with hypoxia-response elements (HRE) in their promoter region [23]. Adv Bioeng Biomed Sci Res, 2023 Glucose Transporters and Metabolic Enzymes Link in The Warburg Effec 1.…”

Section: Krasmentioning

confidence: 99%

“…Adv Bioeng Biomed Sci Res, 2023 Glucose Transporters and Metabolic Enzymes Link in The Warburg Effec 1. Glucose Transporters (GLUT 1-4): Glucose transporters 1 and 3 were the earliest to be discovered as HIF targets due to their enhancement of Glucose transport which facilitated the Warburg effect (23). Studies have demonstrated very strong associations between GLUT 1 expression and the Warburg effect.…”

Section: Krasmentioning

confidence: 99%

Participation of Na+ Channels in Epilepsy: A Bibliometric Analysis of the Scientific Production in the World

2023

Adv Bioeng Biomed Sci Res

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The physical chemistry, biochemistry and physiology strive to research life and life processes. A difficulty arises from the connection with the evolutionary processes. This basic dependency is particularly bound by the basis of physical processes. Quantum mechanical explicable phenomena play an outstanding role. The life forms of our habitat are so high and diverse that the analysis of the life processes and their dynamics are difficult to differentiate. Nevertheless, it can be said to date with the current state of science that physical laws and reactions are the starting point for development. Atoms and molecules have formed the energy of space. The kinetic energy of the chaos enabled the development of prebiotic molecules and, in interaction with the medium water, the development of life forms began in our habitat earth.

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“…41,48,49,50 There are different factors that can lead to a switch to the Warburg effect, 42 such as mitochondrial defects and increased expression or amplification of relevant genes 51 that, when overexpressed, contribute to increased glycolysis observed in cancer cells, including testicular cancer, promoting tumour growth and aggressiveness. 41,52 In cancer, some of the genes that are overexpressed in glycolysis include hexokinase-1, hexokinase-2, glucose phosphate isomerase, aldolase A and glyceraldehyde-3-phosphate dehydrogenase. Hexokinase-1 and -2 are enzymes that catalyse conversion of glucose to glucose-6-phosphate, a first step in glycolysis.…”

Section: Mitochondria In Testicular Cancermentioning

confidence: 99%

Sperm mitochondria dysfunction in response to testicular cancer

Qasemi,

Sur,

Simonik

et al. 2023

Eur J Clin Investigation

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Testicular cancer is the most common form of cancer in young men of reproductive age and its incidence is increasing globally. With the currently successful treatment and 95% survival rate, there is a need for deeper understanding of testicular cancer‐related infertility. Most patients with testicular cancer experience semen abnormalities prior to cancer therapy. However, the exact mechanism of the effect of testicular cancer on sperm anomalies is not known. Mitochondria are organelles that play a crucial role in both tumorigenesis and spermatogenesis and their malfunction may be an important factor resulting in sperm abnormalities in testicular cancer patients. Within the scope of this review, we will discuss current knowledge of testicular cancer‐related alterations in the ATP production pathway, a possible pathophysiological switch from oxidative phosphorylation (OXPHOS) to glycolysis, as well as the role of oxidative stress promoting sperm dysfunction. In this regard, the review provides a summary of the impact of testicular cancer on sperm quality as a possible consequence of impaired mitochondrial function including the energy metabolic pathways that are known to be altered in the sperm of testicular cancer patients.

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Revisiting the Warburg Effect with Focus on Lactate

Cited by 34 publications

References 142 publications

Multi-Omics and Management of Follicular Carcinoma of the Thyroid

Multi-Omics and Management of Follicular Carcinoma of the Thyroid

Participation of Na+ Channels in Epilepsy: A Bibliometric Analysis of the Scientific Production in the World

Sperm mitochondria dysfunction in response to testicular cancer

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