Revitalization of pulpless open apex teeth in rhesus monkeys, using collagen-calcium phosphate gel

Nevins, Alan J.; Finkelstein, Frances; Borden, Bernard G.; LaPorta, Robert F.

doi:10.1016/s0099-2399(76)80058-1

Cited by 56 publications

(21 citation statements)

References 11 publications

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“…Several investigators experimentally infected the root canals of immature teeth in monkeys and produced apical periodontitis in these animals (21)(22)(23)(24)(25)(26). After debridement, disinfection, production of a blood clot, and sealing of the root canals, the authors examined the extent of tissue growth and the types of tissues present in the root canals.…”

Section: Discussionmentioning

confidence: 99%

An Animal Model to Study Regenerative Endodontics

Torabinejad

Corr

Buhrley

et al. 2011

Journal of Endodontics

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Section: Discussionmentioning

confidence: 99%

An Animal Model to Study Regenerative Endodontics

Torabinejad

Corr

Buhrley

et al. 2011

Journal of Endodontics

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“…If pulp and apical papilla are totally lost, then the root canal space may be occupied by cementum, PDL, and bone (35)(36)(37)(38)(39)(40). By tracing the migration of periodontal cells after pulpectomy in immature teeth, Vojinovic and Vojinovic (41) found that periodontal cells migrate into the apical pulp space during the repair process.…”

Section: The Potential Role Of Scap In Replantation and Transplantationmentioning

confidence: 99%

The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering

Huang

Sonoyama

Liu

et al. 2008

Journal of Endodontics

657

543

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Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment. A call for a paradigm shift and new protocol for the clinical management of these cases has been brought to attention. Concomitantly, a new population of mesenchymal stem cells residing in the apical papilla of permanent immature teeth recently has been discovered and was termed stem cells from the apical papilla (SCAP). These stem cells appear to be the source of odontoblasts that are responsible for the formation of root dentin. Conservation of these stem cells when treating immature teeth may allow continuous formation of the root to completion. This article reviews current findings on the isolation and characterization of these stem cells. The potential role of these stem cells in the following respects will be discussed: (1) their contribution in continued root maturation in endodontically treated immature teeth with periradicular periodontitis or abscess and (2) their potential utilization for pulp/ dentin regeneration and bioroot engineering. KeywordsApexogenesis; apical papilla; bioroot engineering; dental pulp stem cells; immature teeth; periodontal ligament stem cells; pulp regeneration; stem cells from human exfoliated deciduous teeth; stem cells from the apical papilla A number of recent clinical case reports have revealed the possibilities that many teeth that traditionally would receive apexification may be treated for apexogenesis. A call for a paradigm shift and new protocol for the clinical management of these cases has been made by the authors (1-3). A recent scientific finding, which may explain in part why apexogenesis can occur in these infected immature permanent teeth, is the discovery and isolation of a new population of mesenchymal stem cells (MSCs) residing in the apical papilla of incompletely developed teeth (4,5). These cells are termed stem cells from the apical papilla (SCAP), and they differentiate

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“…Although the radiographic appearance of apical closure and canal wall thickening can give the impression that a normal, functional pulp has regenerated, there is no histologic evidence to support these findings. There are several animal studies (3,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) examining the nature of tissues present in the root canals of teeth treated with regeneration procedures (Table 2). Connective tissue, cementum, and bone have been reported in these teeth.…”

mentioning

confidence: 99%