Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy

Bala, Rajni; Madaan, Reecha; Chauhan, Samrat; Gupta, Malika; Dubey, Ankit Kumar; Zahoor, Ishrat; Brijesh, Hemavathi; Calina, Daniela; Sharifi-Rad, Javad

doi:10.1007/s00210-023-02675-3

Cited by 8 publications

(2 citation statements)

References 95 publications

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“…This study sought to evaluate the anticancer effects of various dietary factors, including allicin. The therapeutic effects of the garlic-derived compound allicin on tumor cell apoptosis, proliferation, and infiltration were observed using patients’ clinical samples [ 121 ]. Moving forward, a randomized clinical trial included 20 cancer patients who were administered allicin, with 4.40 mg/g of garlic, for 21–61 days.…”

Section: Allicin and Cancer Hallmarksmentioning

confidence: 99%

Allicin and Cancer Hallmarks

Talib,

Baban,

Azzam

et al. 2024

Molecules

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Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main ingredients in garlic (Allium sativum L.). It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, prostate, and colon cancer. Moreover, allicin may target several cancer hallmarks or fundamental biological traits and functions that influence cancer development and spread. Cancer hallmarks include sustained proliferation, evasion of growth suppressors, metastasis, replicative immortality, angiogenesis, resistance to cell death, altered cellular energetics, and immune evasion. The findings of this review should provide researchers and medical professionals with a solid basis to support fundamental and clinical investigations of allicin as a prospective anticancer drug. This review outlines the anticancer role of allicin in each hallmark of cancer.

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Section: Allicin and Cancer Hallmarksmentioning

confidence: 99%

Allicin and Cancer Hallmarks

Talib,

Baban,

Azzam

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Firstly, due to the unstable chemical properties and unpredictable bioavailability of allicin, further research is needed on purification processes and preparation methods to improve its stability and pharmacological activity. Recent advances in formulation strategies and nanotechnology-based drug delivery systems show promise in addressing these challenges, potentially improving allicin’s solubility, stability, and bioavailability [ 100 , 101 ]. Meanwhile, the targeting technology of nanoscale materials enabled the delivery of active ingredients to the desired action site in sufficient concentrations, enhancing their ability to get absorbed into cells.…”

Section: Limitations Of Clinical Applicationmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

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Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate) is one of the primary natural active ingredients in garlic, which has been proven to have powerful cardioprotective effects and mediate various pathological processes related to CVD, such as inflammatory factor secretion, myocardial cell apoptosis, oxidative stress, and more. Therefore, allicin holds a promising application prospect in the treatment of CVD. This review summarized the biological functions of allicin and its potential mechanisms in CVD, including antioxidation, anti-inflammation, and anti-apoptosis effects. Reckoning with these, we delved into recent studies on allicin’s cardioprotective effects concerning various CVDs, such as atherosclerosis, hypertension, myocardial infarction, arrhythmia, cardiac hypertrophy, heart failure, and cardiotoxicity. Further, considering the tremendous advancement in nanomedicine, nanotechnology-based drug delivery systems show promise in addressing limitations of allicin’s clinical applications, including improving its solubility, stability, and bioavailability. Through this review, we hope to provide a reference for further research on allicin in cardioprotection and drug development. Graphical Abstract

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Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption

Gao,

Xu,

Santhanam

et al. 2024

Food Frontiers

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Drug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC. This study aimed to explore the potential mechanism by which allicin reverses Taxol resistance in NSCLC. The potential mechanism of allicin reversing Taxol resistance in vitro was evaluated using cytotoxicity assays, evaluation of cell autophagy and lysosomal function. In addition, the in vivo model was established to evaluate the effectiveness of allicin in reversing Taxol resistance. The results showed that allicin effectively inhibited cell proliferation, induced apoptosis, and reversed Taxol resistance. It inhibits P‐gp expression, reduces drug efflux, and disrupts cell autophagy. In particular, allicin inhibited Cathepsin B (CTSB), disrupted lysosomal function, blocked autophagy flux, reduced mitochondrial membrane potential, and enhanced the sensitivity to Taxol. Allicin combined with Taxol significantly inhibited the growth of tumor nodules and reduced their number, demonstrating its potential to reverse Taxol resistance in vivo. In summary, allicin reversed Taxol resistance by inhibiting P‐gp and CTSB activity and disrupting the lysosomal‐autophagy pathway. These findings highlight the potential of allicin for cancer treatment and drug development.

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Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy

Cited by 8 publications

References 95 publications

Allicin and Cancer Hallmarks

Allicin and Cancer Hallmarks

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption

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