Reviving colistin

Taglialegna, Agustina

doi:10.1038/s41579-023-00907-0

Cited by 4 publications

(1 citation statement)

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“…The antibiotic colistin is viewed as the last line of defense against multidrug resistant Gram-negative bacilli infections, but the minimum inhibitory concentration of colistin is increasing due to the widespread dissemination of mobile mucin resistance (MCR) genes. Therefore, new strategies need to be developed to improve the efficacy of colistin (Taglialegna, 2023). Due to the different pharmacokinetics and hydrophilicity of curcumin and colistin, it is difficult to directly co-deliver the two to the site of infection.…”

Section: Efflux Pumpmentioning

confidence: 99%

Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Zhang,

Liu,

Guo

et al. 2024

WIREs Nanomed Nanobiotechnol

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The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating bacterial infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due to the slow development of new antibiotics and the increase of bacterial drug resistance. Consequently, developing new a\ntimicrobial strategies and improving antibiotic efficacy to combat bacterial infection has become an urgent priority. The emergence of nanotechnology has revolutionized the traditional antibiotic treatment, presenting new opportunities for refractory bacterial infection. Here we comprehensively review the research progress in nanotechnology‐based antimicrobial drug delivery and highlight diverse platforms designed to target different bacterial resistance mechanisms. We also outline the use of nanotechnology in combining antibiotic therapy with other therapeutic modalities to enhance the therapeutic effectiveness of drug‐resistant bacterial infections. These innovative therapeutic strategies have the potential to enhance bacterial susceptibility and overcome bacterial resistance. Finally, the challenges and prospects for the application of nanomaterial‐based antimicrobial strategies in combating bacterial resistance are discussed.This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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Section: Efflux Pumpmentioning

confidence: 99%